Ferrer Juan, Jiang Qixiang, Menner Angelika, Bismarck Alexander
Polymer & Composite Engineering (PaCE) Group, Institute of Materials Chemistry & Research, Faculty of Chemistry, University of Vienna, Währinger Straße 42, A-1090 Vienna, Austria; Microinstrumentation Lab, Engineering Science, Simon Fraser University, 8888 University Drive, Burnaby V5A1S6, Canada.
Polymer & Composite Engineering (PaCE) Group, Institute of Materials Chemistry & Research, Faculty of Chemistry, University of Vienna, Währinger Straße 42, A-1090 Vienna, Austria.
J Colloid Interface Sci. 2022 Jun 15;616:834-845. doi: 10.1016/j.jcis.2022.02.053. Epub 2022 Feb 16.
A tubular co-flow reactor to produce macroporous polymer beads by polymerization of medium and high internal phase emulsion (M/HIPE) templates was developed. This reactor allows for improved production rates compared to tubing based microfluidic devices. Water-in-oil (W/O) M/HIPEs, containing methyl methacrylate (MMA) and ethylene glycol dimethacrylate (EGDMA) monomers in the continuous phase, were injected into a re-circulating carrier phase. The continuous phase of the emulsion droplets was UV polymerized in situ, resulting in polyM/HIPE beads. The emulsion composition was adjusted to produce poly(MMA-co-EGDMA) porous polymer beads with a protective crust and an interconnected internal pore structure. HCl loaded beads were produced by adding the active ingredient into the dispersed emulsion phase, leading to HCl encapsulation in the porous structure of the beads after polymerization. Even after exposure to ambient conditions for 24 h, 60% of the HCl remained in the beads, indicating good encapsulation efficiencies. Thus, it is possible to use such macroporous beads as delivery vehicles.
开发了一种管式并流反应器，用于通过中高内相乳液（M/HIPE）模板的聚合反应生产大孔聚合物珠粒。与基于微流控的管式装置相比，该反应器可提高生产率。将油包水（W/O）M/HIPE乳液（连续相中含有甲基丙烯酸甲酯（MMA）和乙二醇二甲基丙烯酸酯（EGDMA）单体）注入循环载体相中。乳液滴的连续相在原位进行紫外光聚合，得到聚M/HIPE珠粒。调节乳液组成以制备具有保护壳和相互连通的内部孔结构的聚（MMA-co-EGDMA）多孔聚合物珠粒。通过将活性成分添加到分散的乳液相中制备负载HCl的珠粒，聚合后导致HCl封装在珠粒的多孔结构中。即使在暴露于环境条件24小时后，仍有60%的HCl保留在珠粒中，表明具有良好的封装效率。因此，有可能将这种大孔珠粒用作递送载体。
