Nicotinamide Adenine Dinucleotide in the Development and Treatment of Cardiac Remodeling and Aging.

BACKGROUND

Recently, the beneficial effects of nicotinamide adenine dinucleotide (NAD) as an antiaging and antioxidant molecule have become a focus of research. However, the mechanisms by which NAD supplementation affects the associated metabolites under physiological conditions remain unclear. Specifically, although NAD is involved in several processes that are dysregulated in cardiovascular diseases, some effects of NAD precursors and NAD on cardiac diseases have started to gain recognition only recently.

OBJECTIVE

To discuss the influence of NAD supplementation on adverse cardiac remodeling and aging.

RESULTS

Supplementation with NAD precursors or nicotinamide riboside, which enhances or supplements the NADmetabolome, might have a protective effect on the heart. NAD can alleviate chronic heart failure via mitochondrial oxidation-reduction (redox) state mechanism. Furthermore, NAD replenishment can improve the life span of mice.

CONCLUSION

NAD exerts considerable antiaging and antioxidant effects with promising therapeutic effects. However, its effect on humans and its use as a dietary supplement need to be studied further.