Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1 Dahua Road, Dong Dan, Beijing 100730, P.R. China.
Hefei Knature Bio-pharm Co., Ltd., No. 32 Meichong Lake Road, Hefei, P.R. China.
Mini Rev Med Chem. 2022;22(18):2310-2317. doi: 10.2174/1389557522666220304121917.
Recently, the beneficial effects of nicotinamide adenine dinucleotide (NAD) as an antiaging and antioxidant molecule have become a focus of research. However, the mechanisms by which NAD supplementation affects the associated metabolites under physiological conditions remain unclear. Specifically, although NAD is involved in several processes that are dysregulated in cardiovascular diseases, some effects of NAD precursors and NAD on cardiac diseases have started to gain recognition only recently.
To discuss the influence of NAD supplementation on adverse cardiac remodeling and aging.
Supplementation with NAD precursors or nicotinamide riboside, which enhances or supplements the NADmetabolome, might have a protective effect on the heart. NAD can alleviate chronic heart failure via mitochondrial oxidation-reduction (redox) state mechanism. Furthermore, NAD replenishment can improve the life span of mice.
NAD exerts considerable antiaging and antioxidant effects with promising therapeutic effects. However, its effect on humans and its use as a dietary supplement need to be studied further.
最近，烟酰胺腺嘌呤二核苷酸（NAD）作为一种抗衰老和抗氧化分子的有益作用成为研究的焦点。然而，在生理条件下，NAD 补充如何影响相关代谢物的机制尚不清楚。具体来说，尽管 NAD 参与了心血管疾病中失调的几个过程，但 NAD 前体和 NAD 对心脏病的一些影响直到最近才开始得到认可。
讨论 NAD 补充对心脏不良重构和衰老的影响。
补充 NAD 前体或烟酰胺核糖苷，可增强或补充 NAD 代谢组，可能对心脏有保护作用。NAD 可以通过线粒体氧化还原（氧化还原）状态机制缓解慢性心力衰竭。此外，NAD 补充可以延长小鼠的寿命。
NAD 具有显著的抗衰老和抗氧化作用，具有有前景的治疗效果。然而，其对人类的影响及其作为膳食补充剂的使用仍需进一步研究。
