体外研究达氟沙星对高度左氧氟沙星耐药的侵袭性肺炎链球菌分离株的活性。
In vitro activity of delafloxacin against highly levofloxacin-resistant invasive isolates of Streptococcus pneumoniae.
机构信息
Servicio de Microbiología y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Departamento de Medicina, Facultad de Medicina, Universidad Complutense, Madrid, Spain.
Laboratorio de Microbiología, Hospital Santa Bárbara, Puertollano (Ciudad Real), Spain.
出版信息
Enferm Infecc Microbiol Clin (Engl Ed). 2022 Mar;40(3):131-133. doi: 10.1016/j.eimce.2020.09.009.
INTRODUCTION
We report the activity of delafloxacin, a new fluoroquinolone with high affinity for both topoisomerase IV and DNA gyrase, against highly-levofloxacin-resistant invasive strains of Streptococcus pneumoniae.
METHODS
A total of 173 highly-levofloxacin-resistant (MIC>32mg/L) S. pneumoniae invasive isolates were studied. The strains were isolated from blood (n=162) and other sterile fluids (n=11). Serotyping was performed by the Pneumotest-Latex and Quellung reaction. Delafloxacin, levofloxacin, penicillin, cefotaxime, erythromycin and vancomycin MICs were determined by the gradient diffusion method following EUCAST guidelines and breakpoints.
RESULTS
Among the isolates, 32.9% were penicillin non-susceptible, 19.7% cefotaxime non-susceptible, and 76.9% erythromycin resistant. All were susceptible to vancomycin. Delafloxacin MIC and MIC (mg/L) values were 0.064 and 0.12, respectively; 60% (15/25) of serotype 9V isolates showed delafloxacin MICs≥0.12mg/L.
CONCLUSIONS
Delafloxacin was very active against highly-levofloxacin-resistant invasive isolates of S. pneumoniae. Isolates belonging to serotype 9V showed higher delafloxacin MIC values.
简介
我们报告了德拉沙星的活性，这是一种新型氟喹诺酮类药物，对拓扑异构酶 IV 和 DNA 回旋酶具有高亲和力，针对高度耐左氧氟沙星的侵袭性肺炎链球菌株。
方法
共研究了 173 株高度耐左氧氟沙星（MIC>32mg/L）的肺炎链球菌侵袭性分离株。这些菌株是从血液（n=162）和其他无菌体液（n=11）中分离出来的。血清分型采用 Pneumotest-Latex 和 Quellung 反应进行。根据 EUCAST 指南和折点，采用梯度扩散法测定德拉沙星、左氧氟沙星、青霉素、头孢噻肟、红霉素和万古霉素的 MIC。
结果
在分离株中，32.9%对青霉素不敏感，19.7%对头孢噻肟不敏感，76.9%对红霉素耐药。所有菌株均对万古霉素敏感。德拉沙星 MIC 和 MIC（mg/L）值分别为 0.064 和 0.12，60%（15/25）的 9V 血清型分离株显示德拉沙星 MIC≥0.12mg/L。
结论
德拉沙星对高度耐左氧氟沙星的侵袭性肺炎链球菌分离株非常有效。属于血清型 9V 的分离株显示出更高的德拉沙星 MIC 值。
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