Konturek S J, Kitler M E, Brzozowski T, Radecki T
Dig Dis Sci. 1986 Aug;31(8):847-52. doi: 10.1007/BF01296054.
Flavonoids reportedly inhibit histidine decarboxylase and reduce gastric mucosal histamine content. We studied the effects of acute and chronic intragastric administration to rats of meciadanol, a new synthetic flavonoid (Zyma S.A., Nyon, Switzerland). The action of meciadanol was compared to that of 16,16-dimethyl PGE2. Meciadanol did not affect acid or pepsin output at any dose used. High doses of 16,16-dimethyl PGE2 reduced both acid and pepsin output. Meciadanol partially prevented aspirin-induced lesions but the prevention required chronic administration of meciadanol. In contrast, a single dose of meciadanol completely prevented ethanol-induced lesions. Chronic administration of meciadanol also completely prevented ethanol-induced lesions. 16,16-Dimethyl PGE2 prevented both aspirin-induced and ethanol-induced lesions in doses that did not affect acid or pepsin output. Meciadanol did not influence the effect that either aspirin or ethanol had on endogenous mucosal PGI2. Thus, the dose range of meciadanol that protected against ulcerogens did not affect either gastric acid secretion or pepsin output. Therefore, we conclude that meciadanol's action represents true cytoprotection, which was previously attributed only to prostaglandins.
据报道，类黄酮可抑制组氨酸脱羧酶并降低胃黏膜组胺含量。我们研究了向大鼠急性和慢性胃内给予一种新的合成类黄酮美西达醇（瑞士尼翁的Zyma S.A.公司生产）的效果。将美西达醇的作用与16,16 - 二甲基前列腺素E2的作用进行了比较。美西达醇在所用的任何剂量下均不影响胃酸或胃蛋白酶的分泌量。高剂量的16,16 - 二甲基前列腺素E2可降低胃酸和胃蛋白酶的分泌量。美西达醇可部分预防阿司匹林诱导的损伤，但这种预防需要长期给予美西达醇。相比之下，单剂量的美西达醇可完全预防乙醇诱导的损伤。长期给予美西达醇也可完全预防乙醇诱导的损伤。16,16 - 二甲基前列腺素E2在不影响胃酸或胃蛋白酶分泌量的剂量下可预防阿司匹林诱导和乙醇诱导的损伤。美西达醇不影响阿司匹林或乙醇对内源性黏膜前列环素I2的作用。因此，美西达醇预防致溃疡物质的剂量范围既不影响胃酸分泌也不影响胃蛋白酶分泌量。所以，我们得出结论，美西达醇的作用代表了真正的细胞保护作用，而这种作用以前仅被认为是前列腺素所特有的。
