• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Commentary: Reduction in C-Peptide Levels and Influence on Pharmacokinetics and Pharmacodynamics of Insulin Preparations: How to Conduct a High-Quality Euglycemic Clamp Study.

作者信息

Liu Hui, Yu Hongling, Li Ting, Yu Yerong

机构信息

Department of General Practice, West China Hospital of Sichuan University, Chengdu, China.

Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, China.

出版信息

Front Pharmacol. 2022 Feb 18;13:843658. doi: 10.3389/fphar.2022.843658. eCollection 2022.

DOI:10.3389/fphar.2022.843658
PMID:35250591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8896261/
Abstract
摘要

相似文献

1
Commentary: Reduction in C-Peptide Levels and Influence on Pharmacokinetics and Pharmacodynamics of Insulin Preparations: How to Conduct a High-Quality Euglycemic Clamp Study.述评：C肽水平降低及对胰岛素制剂药代动力学和药效学的影响：如何开展高质量的正常血糖钳夹研究。
Front Pharmacol. 2022 Feb 18;13:843658. doi: 10.3389/fphar.2022.843658. eCollection 2022.
2
Reduction in C-Peptide Levels and Influence on Pharmacokinetics and Pharmacodynamics of Insulin Preparations: How to Conduct a High-Quality Euglycemic Clamp Study.C肽水平降低及其对胰岛素制剂药代动力学和药效学的影响：如何开展高质量的正常血糖钳夹研究。
Front Pharmacol. 2021 Dec 2;12:786613. doi: 10.3389/fphar.2021.786613. eCollection 2021.
3
[Effect of peripheral hyperinsulinemia on assessment of pharmacokinetics and pharmacodynamics of insulin preparations in euglycemic clamp].[外周高胰岛素血症对正常血糖钳夹试验中胰岛素制剂药代动力学和药效学评估的影响]
Zhonghua Yi Xue Za Zhi. 2019 May 14;99(18):1375-1379. doi: 10.3760/cma.j.issn.0376-2491.2019.18.004.
4
How to Achieve Sufficient Endogenous Insulin Suppression in Euglycemic Clamps Assessing the Pharmacokinetics and Pharmacodynamics of Long-Acting Insulin Preparations Employing Healthy Volunteers.在使用健康志愿者评估长效胰岛素制剂药代动力学和药效学的正常血糖钳夹试验中如何实现足够的内源性胰岛素抑制。
Front Pharmacol. 2022 Jul 22;13:899798. doi: 10.3389/fphar.2022.899798. eCollection 2022.
5
Oscillations of C-peptide in the euglycemic clamp and their effect on the pharmacodynamic assessment of insulin preparations.在正常血糖钳夹中 C 肽的波动及其对胰岛素制剂药效评估的影响。
Fundam Clin Pharmacol. 2021 Aug;35(4):771-780. doi: 10.1111/fcp.12628. Epub 2020 Nov 20.
6
A comparison of the steady-state pharmacokinetics and pharmacodynamics of a novel rapid-acting insulin analog, insulin glulisine, and regular human insulin in healthy volunteers using the euglycemic clamp technique.采用正常血糖钳夹技术，对新型速效胰岛素类似物门冬胰岛素和常规人胰岛素在健康志愿者中的稳态药代动力学和药效学进行比较。
Exp Clin Endocrinol Diabetes. 2005 May;113(5):292-7. doi: 10.1055/s-2005-865637.
7
[Quality Assessment of Euglycemic Glucose Clamp Test].[正常血糖葡萄糖钳夹试验的质量评估]
Sichuan Da Xue Xue Bao Yi Xue Ban. 2019 Jul;50(4):588-593.
8
Comparison of the Pharmacokinetics and Pharmacodynamics of LY2963016 Insulin Glargine and EU- and US-Approved Versions of Lantus Insulin Glargine in Healthy Subjects: Three Randomized Euglycemic Clamp Studies.在健康受试者中比较 LY2963016 甘精胰岛素和 EU 和美国批准的 Lantus 甘精胰岛素的药代动力学和药效学：三项随机等血糖钳夹研究。
Diabetes Care. 2015 Dec;38(12):2226-33. doi: 10.2337/dc14-2623. Epub 2015 Aug 25.
9
Estimates of in vivo insulin action in man: comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies.人体体内胰岛素作用的评估：胰岛素耐量试验与正常血糖及高血糖葡萄糖钳夹研究的比较
J Clin Endocrinol Metab. 1989 Feb;68(2):374-8. doi: 10.1210/jcem-68-2-374.
10
Circulating endothelin-1 levels increase during euglycemic hyperinsulinemic clamp in lean NIDDM men.在体重正常的非胰岛素依赖型糖尿病男性进行正常血糖高胰岛素钳夹试验期间，循环内皮素-1水平升高。
Diabetes Care. 1995 Feb;18(2):226-33. doi: 10.2337/diacare.18.2.226.

本文引用的文献

1
Reduction in C-Peptide Levels and Influence on Pharmacokinetics and Pharmacodynamics of Insulin Preparations: How to Conduct a High-Quality Euglycemic Clamp Study.C肽水平降低及其对胰岛素制剂药代动力学和药效学的影响：如何开展高质量的正常血糖钳夹研究。
Front Pharmacol. 2021 Dec 2;12:786613. doi: 10.3389/fphar.2021.786613. eCollection 2021.
2
Interindividual Variability in the Pharmacodynamic and Pharmacokinetic Characteristics of Recombinant Human Insulin and Insulin Aspart.重组人胰岛素和胰岛素 Aspart 的药效学和药代动力学特征的个体间变异性。
Clin Ther. 2021 Mar;43(3):594-601.e1. doi: 10.1016/j.clinthera.2021.01.008. Epub 2021 Feb 5.
3
Oscillations of C-peptide in the euglycemic clamp and their effect on the pharmacodynamic assessment of insulin preparations.在正常血糖钳夹中 C 肽的波动及其对胰岛素制剂药效评估的影响。
Fundam Clin Pharmacol. 2021 Aug;35(4):771-780. doi: 10.1111/fcp.12628. Epub 2020 Nov 20.
4
Day-to-Day and Within-Day Variability in Glucose-Lowering Effect Between Insulin Degludec and Insulin Glargine (100 U/mL and 300 U/mL): A Comparison Across Studies.德谷胰岛素与甘精胰岛素（100 U/mL和300 U/mL）降血糖效果的日间及日内变异性：跨研究比较
J Diabetes Sci Technol. 2018 Mar;12(2):356-363. doi: 10.1177/1932296817731422. Epub 2017 Sep 26.
5
LY2963016 Insulin Glargine and Insulin Glargine (Lantus) Produce Comparable Pharmacokinetics and Pharmacodynamics at Two Dose Levels.LY2963016 胰岛素甘精和胰岛素甘精（来得时）在两个剂量水平产生可比较的药代动力学和药效学。
Clin Pharmacol Drug Dev. 2017 Nov;6(6):556-563. doi: 10.1002/cpdd.392. Epub 2017 Sep 21.
6
Insulin glargine and its two active metabolites: A sensitive (16pM) and robust simultaneous hybrid assay coupling immunoaffinity purification with LC-MS/MS to support biosimilar clinical studies.甘精胰岛素及其两种活性代谢物：一种灵敏（16皮摩尔）且稳健的同时进行的免疫亲和纯化与液相色谱-串联质谱联用的杂交分析方法，以支持生物类似药临床研究。
J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 15;1063:50-59. doi: 10.1016/j.jchromb.2017.08.018. Epub 2017 Aug 19.
7
Euglycaemic glucose clamp: what it can and cannot do, and how to do it.血糖钳夹技术：能做什么，不能做什么，以及如何做。
Diabetes Obes Metab. 2016 Oct;18(10):962-72. doi: 10.1111/dom.12703. Epub 2016 Jul 13.
8
Comparison of the Pharmacokinetics and Pharmacodynamics of LY2963016 Insulin Glargine and EU- and US-Approved Versions of Lantus Insulin Glargine in Healthy Subjects: Three Randomized Euglycemic Clamp Studies.在健康受试者中比较 LY2963016 甘精胰岛素和 EU 和美国批准的 Lantus 甘精胰岛素的药代动力学和药效学：三项随机等血糖钳夹研究。
Diabetes Care. 2015 Dec;38(12):2226-33. doi: 10.2337/dc14-2623. Epub 2015 Aug 25.
9
Direct comparison of radioimmunoassay and LC-MS/MS for PK assessment of insulin glargine in clinical development.在临床开发中，放射免疫分析法与液相色谱-串联质谱法用于甘精胰岛素药代动力学评估的直接比较。
Bioanalysis. 2014;6(24):3311-23. doi: 10.4155/bio.14.219.
10
Determination of human insulin and its analogues in human blood using liquid chromatography coupled to ion mobility mass spectrometry (LC-IM-MS).采用液相色谱-离子淌度质谱联用技术（LC-IM-MS）测定人血中的人胰岛素及其类似物。
Drug Test Anal. 2014 Nov-Dec;6(11-12):1125-32. doi: 10.1002/dta.1710. Epub 2014 Sep 14.