Hildebrand J
Drugs Exp Clin Res. 1986;12(1-3):167-75.
At present radiation therapy appears to be the only effective adjuvant treatment in malignant supratentorial gliomas (MSG). Six thousand rads given over 6 weeks increase survival significantly, by about 50%, but the addition of a further 1000 rads to the conventional 6000 rad dose may not be beneficial. Radiosensitizers of anoxic cells such as mizonidazole are ineffective. Superfractionation could represent an improvement over conventional radiotherapy. Adjuvant chemotherapy has proved ineffective in the vast majority of trials, with a few exceptions, the most important being the increase of long-term survivors by BCNU. In the author's opinion chemotherapy should be restricted to patients with recurring signs of MSG.
目前，放射治疗似乎是幕上恶性胶质瘤（MSG）唯一有效的辅助治疗方法。在6周内给予6000拉德可显著提高生存率，约提高50%，但在传统的6000拉德剂量基础上再增加1000拉德可能并无益处。诸如米索硝唑等乏氧细胞放射增敏剂无效。超分割放疗可能是对传统放疗的一种改进。在绝大多数试验中，辅助化疗已被证明无效，仅有少数例外，其中最重要的是卡氮芥可增加长期存活者数量。作者认为，化疗应仅限于有MSG复发迹象的患者。
