Ferrans V J
Cancer Treat Rep. 1978 Jun;62(6):955-61.
A review is presented of cardiac pathologic changes associated with acute and chronic toxicity of anthracyclines. These changes consist of cardiac dilatation, degeneration and atrophy of the muscle cells, and interstitial edema and fibrosis. The degeneration of cardiac muscle cells is a complex phenomenon that involves the myofibrils, the nucleus, the mitochondria and the membrane systems of the T-tubules, the sarcoplasmic reticulum, and the intercellular junctions. The pathogenesis of these alteration is discussed in terms of the biochemical effects of anthracyclines.
本文综述了与蒽环类药物急慢性毒性相关的心脏病理变化。这些变化包括心脏扩张、心肌细胞变性和萎缩，以及间质水肿和纤维化。心肌细胞变性是一种复杂的现象，涉及肌原纤维、细胞核、线粒体以及横管、肌浆网和细胞间连接的膜系统。从蒽环类药物的生化作用方面讨论了这些改变的发病机制。
