Qiao Lili, Chen Yanfei, Liang Ning, Xie Jian, Deng Guodong, Chen Fangjie, Wang Xiaojuan, Liu Fengjun, Li Yupeng, Zhang Jiandong
Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Province Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, China.
Department of Oncology, Shandong First Medical University, Jinan, China.
Front Oncol. 2022 Feb 16;12:775238. doi: 10.3389/fonc.2022.775238. eCollection 2022.
Radiotherapy exerts a crucial role in curing cancer, however, its treatment efficiency is mostly limited due to the presence of radioresistance. Epithelial-to-mesenchymal transition (EMT) is a biological process that endows the cancer cells with invasive and metastatic properties, as well as radioresistance. Many potential mechanisms of EMT-related radioresistance being reported have broaden our cognition, and hint us the importance of an overall understanding of the relationship between EMT and radioresistance. This review focuses on the recent progresses involved in EMT-related mechanisms in regulating radioresistance, irradiation-mediated EMT program, and the intervention strategies to increase tumor radiosensitivity, in order to improve radiotherapy efficiency and clinical outcomes of cancer patients.
放射疗法在癌症治疗中发挥着关键作用，然而，由于存在放射抗性，其治疗效果大多受到限制。上皮-间质转化（EMT）是一个赋予癌细胞侵袭和转移特性以及放射抗性的生物学过程。许多已报道的与EMT相关的放射抗性潜在机制拓宽了我们的认知，并提示我们全面理解EMT与放射抗性之间关系的重要性。本综述聚焦于EMT相关机制在调节放射抗性、辐射介导的EMT程序以及提高肿瘤放射敏感性的干预策略方面的最新进展，以提高癌症患者的放射治疗效果和临床结局。
