Van Obberghen E, Gammeltoft S
Experientia. 1986 Jul 15;42(7):727-34. doi: 10.1007/BF01941518.
The recent characterization of the human insulin receptor structure and its intrinsic tyrosine kinase activity represent major advances in our understanding of the mechanism of insulin action. It is reasonable to think that the insulin-induced autophosphorylation and activation of its receptor kinase represent an important event in the action of insulin on cell metabolism and growth. The fundamental research reviewed may be followed by the discovery of molecular receptor defects in clinical syndromes of insulin resistance.
近期对人类胰岛素受体结构及其内在酪氨酸激酶活性的表征，代表了我们在理解胰岛素作用机制方面取得的重大进展。有理由认为，胰岛素诱导的自身磷酸化及其受体激酶的激活是胰岛素对细胞代谢和生长作用中的一个重要事件。在综述的基础研究之后，可能会发现胰岛素抵抗临床综合征中的分子受体缺陷。
