Jiang Shan, Cui Ju, Zhang Li-Qun, Liu Zhen, Zhang Yan, Shi Yuan, Cai Jian-Ping
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, Beijing, China.
National Center of Gerontology, National Health Commission, Beijing, China.
Front Med (Lausanne). 2022 Feb 18;9:816822. doi: 10.3389/fmed.2022.816822. eCollection 2022.
Healthy aging is described as a process of developing and maintaining intrinsic abilities, including physical and cognitive functions. Although oxidative stress is a common mechanism shared by loss of muscle strength and dementia, its relationship with decreased physical performance and cognitive impairment remains unclear. We aimed to investigate the role of urinary 8-oxo-7, 8-dihydroguanosine (8-oxoGsn), a biomarker of oxidative damage to RNA, in physical and cognitive decline.
The study followed a cross-sectional design and recruited 40-94-year-old inhabitants of Beijing, China (471 men and 881 women). The physical performance of the participants was assessed using handgrip strength, walking speed, and the repeated chair stand test. The cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) 5-min protocol. Urinary 8-oxoGsn levels were measured for all participants.
Participants with high urinary 8-oxoGsn levels were more likely to have low grip strength, slow walking speed, poor performance in the repeated chair stand test, and low scores on the MoCA 5-min protocol (odds ratio [OR] 3.43, 95% confidence interval [CI]: 1.52-7.76; OR 1.71, 95% CI: 1.16-2.53; OR 2.06, 95% CI: 0.92-4.63; OR 1.75, 95% CI: 1.18-2.58), after adjusting for age, sex, smoking habits, alcohol consumption, hypertension, diabetes, cerebro-cardiovascular disease, and chronic kidney disease.
Elevated levels of oxidative stress are independently associated with cognitive and physical impairment. Thus, these results can help in the early identification and development of strategies for the prevention and treatment of intrinsic capacity decline.
健康老龄化被描述为一个发展和维持内在能力的过程，包括身体和认知功能。尽管氧化应激是肌肉力量丧失和痴呆症共有的一种常见机制，但其与身体机能下降和认知障碍之间的关系仍不明确。我们旨在研究尿8-氧代-7,8-二氢鸟苷（8-氧代鸟苷）（一种RNA氧化损伤的生物标志物）在身体和认知衰退中的作用。
本研究采用横断面设计，招募了年龄在40 - 94岁的中国北京居民（471名男性和881名女性）。通过握力、步行速度和重复起坐测试评估参与者的身体机能。使用蒙特利尔认知评估量表（MoCA）5分钟协议评估认知功能。对所有参与者测量尿8-氧代鸟苷水平。
在调整年龄、性别、吸烟习惯、饮酒、高血压、糖尿病、心脑血管疾病和慢性肾病后，尿8-氧代鸟苷水平高的参与者更有可能握力低、步行速度慢、重复起坐测试表现差以及在MoCA 5分钟协议中得分低（优势比[OR] 3.43，95%置信区间[CI]：1.52 - 7.76；OR 1.71，95% CI：1.16 - 2.53；OR 2.06，95% CI：0.92 - 4.63；OR 1.75，95% CI：1.18 - 2.58）。
氧化应激水平升高与认知和身体损伤独立相关。因此，这些结果有助于早期识别并制定预防和治疗内在能力下降的策略。
