Department of Ophthalmology, 162315Erzincan Binali Yıldırım University, Faculty of Medicine, Erzincan, Turkey.
Department of Ophthalmology, 64159Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.
Eur J Ophthalmol. 2022 Nov;32(6):3514-3521. doi: 10.1177/11206721221086240. Epub 2022 Mar 7.
25-hydroxyvitamin D 25(OH)D] sufficiency has critical biological importance for the human body. Although there are several studies on the association between serum 25(OH)D levels and macular structure, the data in this regard are limited. This study mainly aimed to investigate macular microvascular structure using optical coherence tomography angiography (OCTA) in 25(OH)D deficiency.
Prospective, single-center, clinical study.
The study included 82 eyes of 82 patients with 25(OH)D deficiency (Group I) and 50 eyes of 50 healthy subjects (Group II). All participants underwent OCTA examinations. The foveal avascular zone (FAZ) and superficial capillary plexus (SCP) and deep capillary plexus (DCP) vessel density (VD) measurements of the participants were statistically compared between the patients and healthy subjects.
The mean 25(OH)D levels measured from the venous blood samples of the participants were 7.61 ± 3.27 ng/mL in Group I and 25.39 ± 4.16 ng/mL in Group II, and the difference between these values was statistically significant (p 0.0001). The FAZ measurement was significantly higher in Group I. The VDs of the SCP and DCP measurements were significantly higher in Group II. When the central macular thickness values of the participants were compared, Group II had a significantly higher value, but there was no significant difference in the central macular volume and retinal nerve fiber layer thickness analyses.
The results showed that the FAZ area was significantly higher and the VDs of SCP and DCP were significantly lower in the patients with 25(OH)D deficiency. We found that 25(OH)D deficiency affected macular microvascular architecture.
25-羟维生素 D [25（OH）D] 充足对人体具有重要的生物学意义。虽然有几项关于血清 25（OH）D 水平与黄斑结构之间关系的研究，但这方面的数据有限。本研究主要旨在通过光学相干断层扫描血管造影（OCTA）研究 25（OH）D 缺乏症患者的黄斑微血管结构。
前瞻性、单中心、临床研究。
该研究纳入了 82 例 25（OH）D 缺乏症患者（I 组）的 82 只眼和 50 名健康对照者（II 组）的 50 只眼。所有参与者均接受 OCTA 检查。对患者和健康受试者的黄斑中心凹无血管区（FAZ）和浅层毛细血管丛（SCP）及深层毛细血管丛（DCP）血管密度（VD）测量值进行统计学比较。
I 组患者静脉血样本中测量的平均 25（OH）D 水平为 7.61±3.27ng/ml，II 组为 25.39±4.16ng/ml，两组间差异有统计学意义（p<0.0001）。I 组的 FAZ 测量值明显更高。II 组的 SCP 和 DCP 测量 VD 明显更高。当比较参与者的中心黄斑厚度值时，II 组的数值明显更高，但在中心黄斑体积和视网膜神经纤维层厚度分析中无显著差异。
结果表明，25（OH）D 缺乏症患者的 FAZ 面积明显增大，SCP 和 DCP 的 VD 明显降低。我们发现 25（OH）D 缺乏会影响黄斑微血管结构。
