晚期早产新生儿惊厥的产前因素*

Antenatal factors for neonatal seizures among late preterm births*.

作者信息

McLaren Rodney, Clark Maureen, Narayanamoorthy Sujatha, Rastogi Shantanu

机构信息

Division of Maternal-Fetal Medicine, Department of Obstetrics/Gynecology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.

Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, NY, USA.

出版信息

J Matern Fetal Neonatal Med. 2022 Dec;35(25):9544-9548. doi: 10.1080/14767058.2022.2047924. Epub 2022 Mar 6.

DOI:10.1080/14767058.2022.2047924

PMID:35253602

Abstract

OBJECTIVE

The objective of this study was to evaluate for antenatal risk factors for neonatal seizures among late preterm births.

STUDY DESIGN

This was a case control study which included late preterm births without anomaly from the United States Natality database. Cases were infants with neonatal seizures, while the controls consisted of infants without neonatal seizures. Maternal and pregnancy characteristics were compared. Multivariable logistic regression was performed to investigate risk factors for neonatal seizures.

RESULTS

Of the 943,580 late preterm births, 512 (0.05%) developed neonatal seizures. Significant risk factors associated with neonatal seizures among late preterm births included number of prenatal visits (adjusted odds ratio [aOR] 0.94, 95% CI [0.92-0.96]), smoking history (aOR 1.78, 95% CI [1.41-2.25]), chorioamnionitis (aOR 4.37, 95% CI [2.65-7.21]), non-Hispanic White race (aOR 1.41, 95% CI [1.13-1.76]), and cesarean birth (aOR 2.31, 95% CI [1.91-2.80]).

CONCLUSION

Number of prenatal visits, history of smoking, chorioamnionitis, non-Hispanic white race, and cesarean birth are risk factors for neonatal seizures at late preterm gestation.

摘要

目的

本研究的目的是评估晚期早产新生儿癫痫发作的产前危险因素。

研究设计

这是一项病例对照研究，纳入了来自美国出生数据库的无异常的晚期早产病例。病例为患有新生儿癫痫的婴儿，而对照组为由无新生儿癫痫的婴儿组成。比较了母亲和妊娠特征。进行多变量逻辑回归以研究新生儿癫痫发作的危险因素。

结果

在943,580例晚期早产中，512例（0.05%）发生了新生儿癫痫发作。晚期早产中与新生儿癫痫发作相关的显著危险因素包括产前检查次数（调整优势比[aOR]0.94，95%置信区间[CI][0.92 - 0.96]）、吸烟史（aOR 1.78，95%CI[1.41 - 2.25]）、绒毛膜羊膜炎（aOR 4.37，95%CI[2.65 - 7.21]）、非西班牙裔白人种族（aOR 1.41，95%CI[1.13 - 1.76]）和剖宫产（aOR 2.31，95%CI[1.91 - 2.80]）。