Cinelli M, Costa V, Ventresca G P, Lodola E
Int J Clin Pharmacol Ther Toxicol. 1986 May;24(5):232-5.
The analgesic activity of Viminol R2 was compared to that of Pentazocine and placebo in a double-blind, "between subjects" study involving 42 patients with postoperative pain randomly assigned to 3 groups of 14 patients each and treated with a single intravenous dose of Viminol R2 10 mg, Pentazocine 30 mg or placebo. Pain relief scores were recorded over a 2 h period after treatment. The analgesic activity of Viminol R2 and Pentazocine was significantly greater than that of placebo both in terms of time-course of action and frequency of classes of satisfactory analgesia. No statistically significant differences were found between Viminol R2 and Pentazocine. No side effects were observed in any patients treated with Viminol R2.
在一项双盲、“受试者间”研究中，将Viminol R2的镇痛活性与喷他佐辛和安慰剂进行了比较。该研究纳入了42例术后疼痛患者，随机分为3组，每组14例，分别接受单次静脉注射10 mg Viminol R2、30 mg喷他佐辛或安慰剂治疗。治疗后2小时记录疼痛缓解评分。就作用时间进程和满意镇痛等级频率而言，Viminol R2和喷他佐辛的镇痛活性均显著高于安慰剂。Viminol R2和喷他佐辛之间未发现统计学上的显著差异。接受Viminol R2治疗的任何患者均未观察到副作用。
