Chen Lvshuang, Wu Hanyu, Li Yongxiang, Feng Xiajie, Zhu Shuqing, Xie Kailai, Wu Xin, Sun Zhonghua, Shu Gang, Wang Songbo, Gao Ping, Zhu Xiaotong, Zhu Canjun, Jiang Qingyan, Wang Lina
Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, Guangdong, China; College of Animal Science, South China Agricultural University, China.
Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, Guangdong, China; College of Animal Science, South China Agricultural University, China.
Biochem Biophys Res Commun. 2022 Apr 30;602:77-83. doi: 10.1016/j.bbrc.2022.02.109. Epub 2022 Mar 1.
Heat stress is an important factor that affects food intake. Previous studies have proven that heat stress can regulate feeding behavior through a homeostasis pathway and decrease appetite in animals and humans. However, the relationship between heat stress and midbrain reward regulation has not been reported. Corticotropin-releasing factor receptor type 2 (CRFR2) is the receptor of corticotropin-releasing factor (CRF), which is the key hypothalamic pituitary adrenal axis (HPA axis) regulating the stress response. In our study, the effects of heat stress on hedonic feeding behavior were investigated. The results showed that heat stress can affect hedonic feeding behavior and decrease high-fat diet (HFD) intake. Furthermore, the mRNA expression of tyrosine hydroxylase in the VTA decreased under heat stress compared with that at 25 °C. Meanwhile, intraventricular injection of a CRFR2 antagonist reversed the decrease in HFD intake and conditional place preference (CPP) caused by heat stress. In conclusion, CRFR2 in the midbrain plays an important role in the decrease in hedonic feeding behavior caused by heat stress.
热应激是影响食物摄入量的一个重要因素。先前的研究已经证明，热应激可通过内稳态途径调节摄食行为，并降低动物和人类的食欲。然而，热应激与中脑奖赏调节之间的关系尚未见报道。促肾上腺皮质激素释放因子受体2（CRFR2）是促肾上腺皮质激素释放因子（CRF）的受体，而CRF是调节应激反应的关键下丘脑-垂体-肾上腺轴（HPA轴）。在我们的研究中，调查了热应激对享乐性摄食行为的影响。结果表明，热应激可影响享乐性摄食行为并减少高脂饮食（HFD）的摄入量。此外，与25℃时相比，热应激下中脑腹侧被盖区（VTA）中酪氨酸羟化酶的mRNA表达降低。同时，脑室内注射CRFR2拮抗剂可逆转热应激引起的HFD摄入量减少和条件性位置偏爱（CPP）。总之，中脑中的CRFR2在热应激引起的享乐性摄食行为减少中起重要作用。
