Department of Neurosurgery, Emory University School of Medicine, 1365 Clifton Road, Atlanta, GA 30322, USA.
Department of Neurosurgery, Emory University School of Medicine, 1365 Clifton Road, Atlanta, GA 30322, USA.
Otolaryngol Clin North Am. 2022 Apr;55(2):315-329. doi: 10.1016/j.otc.2021.12.006. Epub 2022 Mar 4.
Cushing disease is a disorder of hypercortisolemia caused by hypersecretion of adrenocorticotropic hormone by a pituitary adenoma and is a rare diagnosis. Cushing disease presents with characteristic clinical signs and symptoms associated with excess cortisol, but diagnosis is difficult and often relies on repeated and varied endocrinologic assays and neuroradiologic investigations. Gold standard treatment is surgical resection of adrenocorticotropic hormone-secreting pituitary adenoma, which is curative. Patients require close endocrinologic follow-up for maintenance of associated neuroendocrine deficiencies and surveillance for potential recurrence. Medications, radiation therapy, and bilateral adrenalectomy are alternative treatments for residual or recurrent disease.
库欣病是一种由垂体腺瘤引起的皮质醇增多症，是一种罕见的诊断。库欣病表现为与皮质醇过多相关的特征性临床体征和症状，但诊断困难，通常依赖于重复和多样化的内分泌检测和神经影像学研究。金标准治疗是手术切除促肾上腺皮质激素分泌的垂体腺瘤，这是一种治愈性治疗。患者需要密切的内分泌随访以维持相关的神经内分泌缺陷，并监测潜在的复发。药物治疗、放射治疗和双侧肾上腺切除术是残留或复发病例的替代治疗方法。
