Preparation and characterization of multi-network hydrogels based on sodium alginate/krill protein/polyacrylamide-Strength, shape memory, conductivity and biocompatibility.

Sodium alginate/krill protein/polyacrylamide (SA/AKP/PAM) hydrogel with "covalent bond-ion complex-hydrogen bond" multi-network structure was prepared by covalent cross-linking and complexion ion crosslinking using SA, AKP, and acrylamide (AM) as raw materials. The effects of ion species (Fe, Ba, Sr, Ca, and Zn) on the structure, morphology, and properties of multi-network hydrogels were studied in detail. The results showed that the mechanical strength of ionic cross-linked hydrogels increased significantly. The compressive strength of Fe cross-linked hydrogels was 5.56 MPa, 16.13 times that of non-ionic crosslinked hydrogels. The results of ionic conductivity measurements showed that hydrogels had significant ionic conductivity and were sensitive to external forces. Interestingly, the hydrogel can be used as a capacitive pen in mobile phone writing, painting and dialing numbers. Moreover, ionic cross-linked hydrogels had a unique three-dimensional porous structure with gradient distribution, excellent shape memory effect, and good biocompatibility. Fe, Ba, Sr, and Ca cross-linked hydrogels were nontoxic and conducive to the adhesion and growth of Schwann cells. These excellent properties of ionic cross-linked SA/AKP/PAM hydrogels have broad applications prospects in flexible electronic devices, sensors, soft electronic skins, and tissue engineering.