Ji Cheng, Zhang Chengcheng, Xu Zeya, Chen Yan, Gan Yanming, Zhou Minghui, Li Lan, Duan Qinying, Huang Tingting, Lin Jinxin
Quanzhou Institute of Equipment Manufacturing, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Quanzhou, Fujian, China.
Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China, Fuzhou, Fujian, China.
Front Bioeng Biotechnol. 2023 May 9;11:1193605. doi: 10.3389/fbioe.2023.1193605. eCollection 2023.
Bacterial infection is a major challenge that could threaten the patient's life in repairing bone defects with implant materials. Developing functional scaffolds with an intelligent antibacterial function that can be used for bone repair is very important. We constructed a drug delivery (HA@TA-CS/SA) scaffold with curcumin-loaded dendritic mesoporous organic silica nanoparticles (DMON@Cur) via 3D printing for antibacterial bone repair. Inspired by the adhesion mechanism of mussels, the HA@TA-CS/SA scaffold of hydroxyapatite (HA) and chitosan (CS) is bridged by tannic acid (TA), which in turn binds sodium alginate (SA) using electrostatic interactions. The results showed that the HA@TA-CS/SA composite scaffold had better mechanical properties compared with recent literature data, reaching 68.09 MPa. It displayed excellent degradation and mineralization capabilities with strong biocompatibility . Furthermore, the antibacterial test results indicated that the curcumin-loaded scaffold inhibited and with 99.99% and 96.56% effectiveness, respectively. These findings show that 3D printed curcumin-loaded HA@TA-CS/SA scaffold has considerable promise for bone tissue engineering.
细菌感染是使用植入材料修复骨缺损时可能威胁患者生命的主要挑战。开发具有智能抗菌功能、可用于骨修复的功能性支架非常重要。我们通过3D打印构建了一种载有姜黄素的树枝状介孔有机硅纳米颗粒（DMON@Cur）的药物递送支架（HA@TA-CS/SA）用于抗菌骨修复。受贻贝粘附机制的启发，羟基磷灰石（HA）和壳聚糖（CS）的HA@TA-CS/SA支架由单宁酸（TA）桥接，TA又通过静电相互作用结合海藻酸钠（SA）。结果表明，与最近的文献数据相比，HA@TA-CS/SA复合支架具有更好的力学性能，达到68.09兆帕。它具有优异的降解和矿化能力，生物相容性强。此外，抗菌测试结果表明，载有姜黄素的支架对[具体细菌1]和[具体细菌2]的抑制效果分别达到99.99%和96.56%。这些发现表明，3D打印的载有姜黄素的HA@TA-CS/SA支架在骨组织工程方面具有很大的前景。
