Chaussain J L, Savage M O, Nahoul K, Brijawi A, Canlorbe P, Job J C
Clin Endocrinol (Oxf). 1978 Jun;8(6):437-44. doi: 10.1111/j.1365-2265.1978.tb02180.x.
Eleven boys aged 1-10 years with central precocious puberty were studied. According to the pubertal development six were classified as P2, one as P3 and four as P5. In all cases plasma testosterone levels were definitely elevated (1.7-5.8 ng/ml) when compared with pre-pubertal controls. Peak values after HCG (3 X 1500 units) in four of the boys were in the high adult range. The binding capacity of serum testosterone oestradiol binding globuline (TeBG) ranged between 0.5 and 7.30 microgram/dl. Basal plasma levels of LH and FSH were respectively 2.06 +/- 0.64 and 1.2 +/- 0.25 miu/ml, and peak levels after LHRH (0.1 mg/m2) 13.9 +/- 3.7 and 2.6 +/- 0.43 miu/ml respectively. The data demonstrated a significant increase of plasma testosterone and post LHRH LH peak levels in boys with central precocious puberty when compared with pre-pubertal controls. The patients at stage P2 exhibited high levels of plasma testosterone contrasting with the degree of pubertal maturation, high values of TeBG and low response to LHRH which were in the pre-pubertal range. These findings suggest that the testicular sensitivity to LH increases early in boys with central precocious puberty, while the testosterone responsiveness, both at peripheral and hypothalamic levels, is delayed.
对11名年龄在1至10岁的中枢性性早熟男孩进行了研究。根据青春期发育情况，6名被归类为P2期，1名被归类为P3期，4名被归类为P5期。与青春期前对照组相比，所有病例的血浆睾酮水平均明显升高（1.7 - 5.8 ng/ml）。4名男孩在注射人绒毛膜促性腺激素（3×1500单位）后的峰值处于成人高值范围。血清睾酮与雌二醇结合球蛋白（TeBG）的结合能力在0.5至7.30微克/分升之间。促黄体生成素（LH）和促卵泡生成素（FSH）的基础血浆水平分别为2.06±0.64和1.2±0.25毫国际单位/毫升，促性腺激素释放激素（LHRH，0.1毫克/平方米）刺激后的峰值水平分别为13.9±3.7和2.6±0.43毫国际单位/毫升。数据表明，与青春期前对照组相比，中枢性性早熟男孩的血浆睾酮和LHRH刺激后LH峰值水平显著升高。处于P2期的患者血浆睾酮水平较高，这与青春期成熟程度、TeBG高值以及对LHRH的低反应形成对比，而这些反应仍处于青春期前范围。这些发现表明，中枢性性早熟男孩的睾丸对LH的敏感性在早期增加，而在外周和下丘脑水平的睾酮反应性则延迟。
