Howard Hughes Medical Institute, Cornell University, Ithaca, NY 14853.
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2117013119. doi: 10.1073/pnas.2117013119. Epub 2022 Mar 8.
SignificanceThe study provided a long-sought molecular mechanism that could explain the link between fatty acid metabolism and cancer metastasis. Further understanding may lead to new strategies to inhibit cancer metastasis. The chemical proteomic approach developed here will be useful for discovering other regulatory mechanisms of protein function by small molecule metabolites.
该研究提供了一个长期以来人们一直寻求的分子机制，可以解释脂肪酸代谢与癌症转移之间的联系。进一步的理解可能会导致新的策略来抑制癌症转移。这里开发的化学蛋白质组学方法将有助于发现小分子代谢物对蛋白质功能的其他调节机制。
Zotero 插件
