Sorbonne Universités, UPMC Univ Paris 06, INSERM, UMR_S 938, Saint-Antoine Research Center, Paris, France.
AP-HP, Hospital Tenon, Service de Biochimie et Hormonologie, Paris, France.
Lab Invest. 2018 Feb;98(2):164-174. doi: 10.1038/labinvest.2017.137.
Nucleoside diphosphate kinases (NDPK) are nucleotide metabolism enzymes encoded by NME genes (also called NM23). Given the fact that not all NME-encoded proteins are catalytically active NDPKs and that NM23 generally refers to clinical studies on metastasis, we use here NME/NDPK to denote the proteins. Since their discovery in the 1950's, NMEs/NDPKs have been shown to be involved in multiple physiological and pathological cellular processes, but the molecular mechanisms have not been fully determined. Recent progress in elucidating these underlying mechanisms has been presented by experts in the field at the 10th International Congress on the NDPK/NME/AWD protein family in October 2016 in Dubrovnik, Croatia, and is summarized in review articles or original research in this and an upcoming issue of Laboratory Investigation. Within this editorial, we discuss three major cellular processes that involve members of the multi-functional NME/NDPK family: (i) cancer and metastasis dissemination, (ii) membrane remodeling and nucleotide channeling, and iii) protein histidine phosphorylation.
核苷二磷酸激酶（NDPK）是由 NME 基因（也称为 NM23）编码的核苷酸代谢酶。鉴于并非所有 NME 编码的蛋白质都是具有催化活性的 NDPK，并且 NM23 通常是指转移的临床研究，因此我们在这里使用 NME/NDPK 来表示这些蛋白质。自 20 世纪 50 年代发现以来，NME/NDPKs 已被证明参与多种生理和病理细胞过程，但分子机制尚未完全确定。在 2016 年 10 月于克罗地亚杜布罗夫尼克举行的第十届 NDPK/NME/AWD 蛋白家族国际会议上，该领域的专家介绍了阐明这些潜在机制的最新进展，并在本期和即将出版的《实验室研究》的综述文章或原始研究中进行了总结。在这篇社论中，我们讨论了涉及多功能 NME/NDPK 家族成员的三个主要细胞过程：（i）癌症和转移传播，（ii）膜重塑和核苷酸通道，以及（iii）蛋白组氨酸磷酸化。
