• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209.

作者信息

Ju Bin, Zheng Qingbing, Guo Huimin, Fan Qing, Li Tingting, Song Shuo, Sun Hui, Shen Senlin, Zhou Xinrong, Xue Wenhui, Cui Lingyan, Zhou Bing, Li Shaowei, Xia Ningshao, Zhang Zheng

机构信息

Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China.

Guangdong Key laboratory for anti-infection Drug Quality Evaluation, Shenzhen, Guangdong, China.

出版信息

Cell Res. 2022 May;32(5):491-494. doi: 10.1038/s41422-022-00638-6. Epub 2022 Mar 8.

DOI:10.1038/s41422-022-00638-6
PMID:35260792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8902274/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/9061816/637dfeb0e929/41422_2022_638_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/9061816/637dfeb0e929/41422_2022_638_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/9061816/637dfeb0e929/41422_2022_638_Fig1_HTML.jpg

相似文献

1
Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）奥密克戎变异株的免疫逃逸及其被一种广泛中和性人类抗体VacW-209有效中和的结构基础
Cell Res. 2022 May;32(5):491-494. doi: 10.1038/s41422-022-00638-6. Epub 2022 Mar 8.
2
Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer.SARS-CoV-2 抗体的结构研究鉴定出一种广谱抗体，通过分解 Spike 三聚体来中和奥密克戎变体。
J Virol. 2022 Aug 24;96(16):e0048022. doi: 10.1128/jvi.00480-22. Epub 2022 Aug 4.
3
Nasal delivery of broadly neutralizing antibodies protects mice from lethal challenge with SARS-CoV-2 delta and omicron variants.鼻腔递送广谱中和抗体可保护小鼠免受 SARS-CoV-2 德尔塔和奥密克戎变异株的致死性攻击。
Virol Sin. 2022 Apr;37(2):238-247. doi: 10.1016/j.virs.2022.02.005. Epub 2022 Feb 18.
4
Novel Monoclonal Antibodies and Recombined Antibodies Against Variant SARS-CoV-2.新型单克隆抗体和针对变异 SARS-CoV-2 的重组抗体
Front Immunol. 2021 Aug 30;12:715464. doi: 10.3389/fimmu.2021.715464. eCollection 2021.
5
Elicitation of Broadly Neutralizing Antibodies against B.1.1.7, B.1.351, and B.1.617.1 SARS-CoV-2 Variants by Three Prototype Strain-Derived Recombinant Protein Vaccines.三种原型株衍生重组蛋白疫苗对 B.1.1.7、B.1.351 和 B.1.617.1 变异 SARS-CoV-2 诱导产生广谱中和抗体。
Viruses. 2021 Jul 22;13(8):1421. doi: 10.3390/v13081421.
6
Antibody Avidity and Neutralizing Response against SARS-CoV-2 Omicron Variant after Infection or Vaccination.感染或接种疫苗后针对 SARS-CoV-2 奥密克戎变异株的抗体亲合力和中和反应。
J Immunol Res. 2022 Aug 31;2022:4813199. doi: 10.1155/2022/4813199. eCollection 2022.
7
A Glycosylated RBD Protein Induces Enhanced Neutralizing Antibodies against Omicron and Other Variants with Improved Protection against SARS-CoV-2 Infection.一种糖基化 RBD 蛋白诱导针对奥密克戎和其他变体的增强型中和抗体，提高对 SARS-CoV-2 感染的保护作用。
J Virol. 2022 Sep 14;96(17):e0011822. doi: 10.1128/jvi.00118-22. Epub 2022 Aug 16.
8
Omicron variant susceptibility to neutralizing antibodies induced in children by natural SARS-CoV-2 infection or COVID-19 vaccine.奥密克戎变异株对儿童自然感染 SARS-CoV-2 或接种 COVID-19 疫苗诱导产生的中和抗体的敏感性。
Emerg Microbes Infect. 2022 Dec;11(1):543-547. doi: 10.1080/22221751.2022.2035195.
9
A booster dose of Delta × Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants.Delta-Omicron 混合 mRNA 疫苗加强针可产生针对奥密克戎和其他 SARS-CoV-2 变体的广谱中和抗体。
J Biomed Sci. 2022 Jul 7;29(1):49. doi: 10.1186/s12929-022-00830-1.
10
A fourth dose of Omicron RBD vaccine enhances broad neutralization against SARS-CoV-2 variants including BA.1 and BA.2 in vaccinated mice.第四针奥密克戎 RBD 疫苗加强了对 vaccinated mice 中 SARS-CoV-2 变异株（包括 BA.1 和 BA.2）的广泛中和作用。
J Med Virol. 2022 Aug;94(8):3992-3997. doi: 10.1002/jmv.27811. Epub 2022 May 6.

引用本文的文献

1
A critical residue in a conserved RBD epitopethe determines neutralization breadth of pan-sarbecovirus antibodies with recurring YYDRxxG motifs.保守的受体结合域（RBD）表位中的一个关键残基决定了具有重复YYDRxxG基序的泛沙贝病毒抗体的中和广度。
mBio. 2025 Jul 31:e0060625. doi: 10.1128/mbio.00606-25.
2
Structure and function of an unusual R452-dependent monoclonal antibody against SARS-CoV-2.一种针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的不寻常的R452依赖性单克隆抗体的结构与功能
J Virol. 2025 May 20;99(5):e0184424. doi: 10.1128/jvi.01844-24. Epub 2025 Apr 8.
3
NIEAs elicited by wild-type SARS-CoV-2 primary infection fail to enhance the infectivity of Omicron variants.
野生型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）初次感染引发的非中和性免疫逃逸抗体（NIEAs）无法增强奥密克戎变体的传染性。
Virol J. 2025 Feb 24;22(1):45. doi: 10.1186/s12985-025-02667-0.
4
Structural insights into hybridoma-derived neutralizing monoclonal antibodies against Omicron BA.5 and XBB.1.16 variants of SARS-CoV-2.针对新冠病毒奥密克戎BA.5和XBB.1.16变体的杂交瘤衍生中和单克隆抗体的结构见解
J Virol. 2025 Feb 25;99(2):e0130724. doi: 10.1128/jvi.01307-24. Epub 2025 Jan 7.
5
Effects of some anti-ulcer and anti-inflammatory natural products on cyclooxygenase and lipoxygenase enzymes: insights from in silico analysis.某些抗溃疡和抗炎天然产物对环氧化酶和脂氧合酶的影响：计算机模拟分析的见解
In Silico Pharmacol. 2024 Nov 2;12(2):97. doi: 10.1007/s40203-024-00269-2. eCollection 2024.
6
Engineering a SARS-CoV-2 Vaccine Targeting the Receptor-Binding Domain Cryptic-Face via Immunofocusing.通过免疫聚焦工程设计一种靶向受体结合域隐蔽面的新型冠状病毒2疫苗
ACS Cent Sci. 2024 Sep 17;10(10):1871-1884. doi: 10.1021/acscentsci.4c00722. eCollection 2024 Oct 23.
7
Broad-Spectrum Engineered Multivalent Nanobodies Against SARS-CoV-1/2.针对严重急性呼吸综合征冠状病毒1/2的广谱工程多价纳米抗体
Adv Sci (Weinh). 2024 Dec;11(45):e2402975. doi: 10.1002/advs.202402975. Epub 2024 Oct 7.
8
Computationally designed Spike antigens induce neutralising responses against the breadth of SARS-COV-2 variants.通过计算设计的刺突抗原可诱导针对新冠病毒变异株广泛范围的中和反应。
NPJ Vaccines. 2024 Sep 9;9(1):164. doi: 10.1038/s41541-024-00950-9.
9
Engineering a SARS-CoV-2 vaccine targeting the RBD cryptic-face via immunofocusing.通过免疫聚焦设计一种靶向RBD隐秘面的新型冠状病毒2疫苗。
bioRxiv. 2024 Jun 5:2024.06.05.597541. doi: 10.1101/2024.06.05.597541.
10
The D Gene in CDR H3 Determines a Public Class of Human Antibodies to SARS-CoV-2.互补决定区H3中的D基因决定了一类针对新冠病毒的公共人类抗体。
Vaccines (Basel). 2024 Apr 27;12(5):467. doi: 10.3390/vaccines12050467.