Abdel-Dayem H M, Mahajan K K, Ericsson S B, Kouris K, Owunwanne A, Nawaz K, Higazi E, Awdeh M
Nucl Med Commun. 1986 May;7(5):381-9.
During the evaluation of 99Tcm-DTPA for localization of acute gastrointestinal bleeding in 81 studies (78 patients), it was observed that there was an increased 99Tcm-DTPA at sites of inflammatory and malignant lesions of the GI tract in 18 studies. Active bleeding was detected only in 10 and no bleeding was detected in the remaining eight studies. In all the increased DTPA uptake helped to localize the site of bleeding. Image subtraction of early from delayed images according to a predefined acquisition and processing protocol helped to differentiate bleeding from non bleeding lesions. We conclude that increased 99Tcm-DTPA uptake in malignant and inflammatory lesions of the bowel is an additional advantage for its use in localizing the site of acute GI bleeding. Technetium-99m diethylenetriamine pentaacetic acid (99Tcm-DTPA) has been widely used for imaging the brain and kidneys since it was introduced by Hauser in 1970. Kadir and Strauss in 1979 reported that 99Tcm-DTPA localizes in segments of bowel with inflammation due to ulcerative colitis, regional enteritis and other forms of enterocolitis. Recently we reported the advantages of 99Tcm-DTPA in localizing the site of acute gastrointestinal bleeding. Inflammatory bowel diseases are among the causes of gastrointestinal bleeding. One of the problems in localizing the site of the bleeding by radionuclide procedures is the intermittent nature of the bleeding. We have reviewed all gastrointestinal bleeding studies in our department using 99Tcm-DTPA from January 1984 till September 1985 in order to find out whether increased uptake of 99Tcm-DTPA was helpful in localizing the bleeding lesion due to malignancy and/or inflammation.
在对81例研究（78例患者）中运用99锝-二乙三胺五乙酸（99Tcm-DTPA）进行急性胃肠道出血定位的评估过程中，发现18例研究中胃肠道炎症和恶性病变部位的99Tcm-DTPA摄取增加。仅在10例中检测到活动性出血，其余8例研究中未检测到出血。在所有摄取增加的DTPA病例中，均有助于确定出血部位。根据预定义的采集和处理方案，对早期图像与延迟图像进行图像相减，有助于区分出血性病变与非出血性病变。我们得出结论，肠道恶性和炎性病变中99Tcm-DTPA摄取增加是其用于定位急性胃肠道出血部位的又一优势。自1970年豪泽引入99锝-二乙三胺五乙酸（99Tcm-DTPA）以来，它已广泛用于脑和肾脏成像。1979年卡迪尔和施特劳斯报告称，99Tcm-DTPA定位于溃疡性结肠炎、局限性肠炎和其他形式的小肠结肠炎所致炎症的肠段。最近我们报告了99Tcm-DTPA在定位急性胃肠道出血部位方面的优势。炎性肠病是胃肠道出血的病因之一。通过放射性核素检查定位出血部位的问题之一是出血的间歇性。我们回顾了1984年1月至1985年9月我们科室使用99Tcm-DTPA进行的所有胃肠道出血研究，以确定99Tcm-DTPA摄取增加是否有助于定位恶性肿瘤和/或炎症所致的出血病变。
