Department of Pathology, Discipline of Pediatrics, Department of Infant Care-Pediatrics-Neonatology, University of Medicine and Pharmacy of Craiova, Romania;
Rom J Morphol Embryol. 2021 Jul-Sep;62(3):743-750. doi: 10.47162/RJME.62.3.11.
The main malignant tumor of the bone tissue is represented by osteosarcoma, neoplasia with a reserved prognosis and an unpredictable evolution, often aggressive. Cell cycle disruption is one of the complex biomolecular mechanisms involved in the progression of osteosarcomas. In this study, we analyzed the immunoexpression of Ki67, p53 and cyclin D1 for 18 primitive osteosarcomas in relation to the clinicopathological prognosis parameters of the lesions. The results indicated the predominance of lesions in male young patients, with femoral location, most tumors being represented by the osteoblastic type, with high grade, size <8 cm and in advanced stages. Reactions were present in all cases, the high immunoexpression being associated with osteoblastic∕epithelioid types (Ki67, cyclin D1, p53), high grade (Ki67, cyclin D1) and advanced stage (Ki67, cyclin D1). The study revealed a positive linear relation of the investigated immunomarkers expression, which indicates their usefulness in identifying lesions with aggressive progression potential.
骨组织的主要恶性肿瘤是骨肉瘤，这是一种预后良好但具有不可预测的进化的肿瘤，通常具有侵袭性。细胞周期紊乱是骨肉瘤进展中涉及的复杂生物分子机制之一。在这项研究中，我们分析了 18 例原始骨肉瘤中 Ki67、p53 和细胞周期蛋白 D1 的免疫表达与病变的临床病理预后参数的关系。结果表明，病变主要发生在年轻男性患者中，位于股骨，大多数肿瘤表现为成骨细胞型，高级别，大小<8cm 且处于晚期。所有病例均存在反应，高免疫表达与成骨∕上皮样型（Ki67、细胞周期蛋白 D1、p53）、高级别（Ki67、细胞周期蛋白 D1）和晚期（Ki67、细胞周期蛋白 D1）相关。该研究揭示了所研究免疫标志物表达之间的正线性关系，这表明它们可用于识别具有侵袭性进展潜力的病变。
