头孢唑林在肾功能正常患者中的吸收、分布及消除

Absorption, distribution and elimination of cefazolin in patients with normal renal function.

作者信息

Bergan T, Digranes A, Schreiner A

出版信息

Chemotherapy. 1978;24(5):277-82. doi: 10.1159/000237793.

Abstract

Cefazolin was given intramuscularly in a dosage of 1.0 g to 13 bed-ridden patients during treatment for various infections, and the pharmacokinetics evaluated in each subject. In 9 patients the mean serum half-life was 2.7 h, whereas in 4 patients--all over 60 years of age--it was significantly above this value. Impaired renal fuction could not explain the prolonged excretion time in the last group.

摘要

在对13名卧床患者进行各种感染治疗期间，给他们肌肉注射了剂量为1.0克的头孢唑林，并对每个受试者的药代动力学进行了评估。9名患者的平均血清半衰期为2.7小时，而4名年龄均超过60岁的患者的半衰期明显高于此值。肾功能受损无法解释最后一组患者排泄时间延长的原因。