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症状性颈动脉狭窄的颈动脉内膜切除术和颈动脉支架置入术:发展中国家杂交神经外科医生的经验。

Carotid Endarterectomy and Carotid Artery Stenting for Symptomatic Carotid Stenosis: An Experience of a Hybrid Neurosurgeon in a Developing Nation.

机构信息

Department of Neurosurgery, Lokmanya Tilak Municipal Medical College and Sion Hospital, Sulochana shetty marg, Sion West, Mumbai, Maharashtra, India.

出版信息

Neurol India. 2022 Jan-Feb;70(1):94-101. doi: 10.4103/0028-3886.336326.

Abstract

BACKGROUND

Stenosis of the ICA is an important cause of ischemic stroke and associated morbidity and mortality. Carotid artery stenting (CAS) and carotid endarterectomy (CEA) help to prevent impending or subsequent ischemic stroke in such patients.

AIM AND OBJECTIVE

To study the outcome and adverse events associated with CEA and CAS. To determine the generalization of results obtained with multicentric trials such as CREST, etc., by comparing the results obtained by a single neurosurgeon in a community setting.

MATERIAL AND METHODS

From Jan 2014-Dec 2017, 80 patients presented with symptomatic carotid stenosis. Out of these 80 patients, 65 underwent intervention; 34 patients underwent CEA and 31 patients underwent CAS. Pre-defined variables like age, sex, and degree of stenosis were assessed as potential risk factors, and the patients' clinical features, radiological imaging, and procedural complications were documented.

RESULTS

The primary outcome of procedure-related stroke, major adverse events (MAEs), and death at 30 days follow-up and long-term outcomes of restenosis at 1 year were analyzed. Peri-procedural stroke occurred in 2 cases (6.4%) of CAS; one suffered an ischemic stroke and other suffered a hemorrhagic stroke. Three cases of CEA suffered procedure-related events; one (2.9%) suffered TIA while the other two developed postoperative local hematoma without neurological deficit; one was treated conservatively while the other required re-exploration due to pressure symptoms. Restenosis occurred in one case that underwent CAS.

CONCLUSION

CAS and CEA are complementary approaches in treating symptomatic carotid stenosis even when performed by a single hybrid neurosurgeon as results obtained are commensurable to major studies like CREST.

摘要

背景

颈内动脉狭窄是缺血性卒中和相关发病率和死亡率的重要原因。颈动脉支架置入术(CAS)和颈动脉内膜切除术(CEA)有助于预防此类患者即将发生或随后发生的缺血性卒中。

目的和目标

研究 CEA 和 CAS 相关的结果和不良事件。通过比较社区环境中单神经外科医生获得的结果,确定 CREST 等多中心试验获得的结果的推广性。

材料和方法

2014 年 1 月至 2017 年 12 月,80 例患者因症状性颈动脉狭窄就诊。在这 80 例患者中,有 65 例接受了介入治疗;34 例患者接受 CEA,31 例患者接受 CAS。评估了年龄、性别和狭窄程度等预定义变量作为潜在的危险因素,并记录了患者的临床特征、影像学和手术并发症。

结果

分析了 30 天随访时与手术相关的卒中、主要不良事件(MAE)和死亡的主要结果以及 1 年时再狭窄的长期结果。CAS 有 2 例(6.4%)发生围手术期卒中;1 例发生缺血性卒中,另 1 例发生出血性卒中。CEA 有 3 例发生与手术相关的事件;1 例(2.9%)发生 TIA,另外 2 例发生术后局部血肿无神经功能缺损;1 例保守治疗,另 1 例因压迫症状需要再次探查。CAS 治疗的 1 例患者发生再狭窄。

结论

即使由单一的杂交神经外科医生进行,CAS 和 CEA 也是治疗症状性颈动脉狭窄的互补方法,因为获得的结果与 CREST 等主要研究相当。

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