剖宫产与子代发生乳糜泻风险增加无关：一项荟萃分析。
Cesarean section is not associated with increased risk of celiac disease in the offspring: a meta-analysis.
机构信息
Department of Gynaecology and Obstetrics, First People's Hospital of Taizhou, Taizhou, China.
Department of Gastroenterology, Hospital of Zhejiang Red Cross, Hangzhou, China.
出版信息
J Matern Fetal Neonatal Med. 2022 Dec;35(25):9570-9577. doi: 10.1080/14767058.2022.2048813. Epub 2022 Mar 9.
OBJECTIVE
Epidemiologic findings are inconsistent concerning the association between cesarean section (C-section) and celiac disease in offspring.
METHODS
We performed a systematic literature search of PubMed and Embase databases until July 2021. A meta-analysis was performed for each outcome in which a summary odds ratio (OR) was calculated while taking heterogeneity into account.
RESULTS
A total of 11 observational were identified for the literature review. We found that C-section was not associated with an increase in the risk of CD (OR = 1.03, 95% CI, 0.95-1.12; = .501). In subgroup analyses, the association remained insignificant for both infants born after elective C-section (OR 1.05; 0.95-1.16; = .329) and emergency C-section (OR 1.06; 1-1.13; = .051).
CONCLUSIONS
Our results indicate that C-section is not associated with CD in offspring.
目的
关于剖宫产（C -section）与后代乳糜泻之间的关联，流行病学研究结果并不一致。
方法
我们对 PubMed 和 Embase 数据库进行了系统的文献检索，检索时间截至 2021 年 7 月。对于每个结局，我们都进行了荟萃分析，在考虑异质性的情况下计算了汇总优势比（OR）。
结果
共确定了 11 项用于文献复习的观察性研究。我们发现剖宫产与 CD 风险增加无关（OR = 1.03，95%CI，0.95-1.12；= 0.501）。在亚组分析中，对于选择性剖宫产（OR 1.05；0.95-1.16；= 0.329）和紧急剖宫产（OR 1.06；1-1.13；= 0.051）出生的婴儿，这种关联仍然不显著。
结论
我们的结果表明剖宫产与后代乳糜泻无关。
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