伴有t(6;21;8)(p23;q22;q22)的急性髓系白血病的良好临床病程

[A favorable clinical course of acute myeloid leukemia with t (6;21;8)(p23;q22;q22)].

作者信息

Wada Atsushi, Doki Noriko, Otsuka Yuki, Adachi Hiroto, Konuma Ryosuke, Kishida Yuya, Konishi Tatsuya, Yamada Yuta, Nagata Akihito, Nagata Ryohei, Marumo Atsushi, Noguchi Yuma, Mukae Junichi, Toya Takashi, Igarashi Aiko, Najima Yuho, Kobayashi Takeshi, Harada Hironori, Harada Yuka, Sakamaki Hisashi, Ohashi Kazuteru

机构信息

Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital.

Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences.

出版信息

Rinsho Ketsueki. 2022;63(2):104-107. doi: 10.11406/rinketsu.63.104.

DOI:10.11406/rinketsu.63.104

PMID:35264498

Abstract

Variants of the t (8;21) (q22;q22) involving chromosome 8, 21, and other chromosomes account for about 3% of all t (8;21) (q22;q22) in patients with acute myeloid leukemia (AML). However, the prognosis of AML with variant t (8;21) remains unknown due to the scarcity of reported cases. Herein we report a case of AML with t (6;21;8) (p23;q22;q22). Fluorescence in situ hybridization confirmed a RUNX1-RUNX1T1 fusion signal on the derivative chromosome 8. This is the first report on a variant of t (8;21) involving the breakpoint 6p23. After induction chemotherapy, our patient achieved complete remission and has been stable for four years.

摘要

涉及8号、21号及其他染色体的t(8;21)(q22;q22)变异型约占急性髓系白血病（AML）患者中所有t(8;21)(q22;q22)的3%。然而，由于报道的病例较少，具有变异型t(8;21)的AML的预后仍然未知。在此，我们报告1例t(6;21;8)(p23;q22;q22)的AML病例。荧光原位杂交证实了衍生8号染色体上存在RUNX1-RUNX1T1融合信号。这是关于涉及断点6p23的t(8;21)变异型的首次报道。诱导化疗后，我们的患者实现了完全缓解，并且已经稳定四年。