Patel Aakash V, Gaffo Angelo L
Tinsley Harrison Internal Medicine Residency Program, University of Alabama at Birmingham, Birmingham, AL, USA.
Division of Rheumatology and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL, USA.
J Inflamm Res. 2022 Mar 3;15:1591-1598. doi: 10.2147/JIR.S284759. eCollection 2022.
Gout is a common inflammatory arthritis that tends to affect significantly more men than women. However, female gout patients are more likely to have comorbidities such as hypertension, diabetes mellitus, and renal dysfunction. Furthermore, they experience a greater disease burden due to gout than males. While nonbiological causes may possibly contribute to this sex discrepancy in burden, this raises questions regarding whether current gout pharmacotherapies are as efficacious in females as they are in males. In this review, we examine how the clinical profile of female gout patients differs from male patients; we then survey the literature for data on outcomes for female gout patients treated with urate-lowering therapies for chronic management of gout as well as commonly used agents for acute flares. We also discuss considerations for managing gout in women during pregnancy and lactation.
痛风是一种常见的炎性关节炎，男性患者明显多于女性。然而，女性痛风患者更易合并高血压、糖尿病和肾功能不全等疾病。此外，她们因痛风承受的疾病负担比男性更重。虽然非生物学因素可能是导致这种负担性别差异的原因之一，但这也引发了关于当前痛风药物疗法在女性患者中是否与男性患者同样有效的问题。在本综述中，我们研究了女性痛风患者与男性患者的临床特征有何不同；然后我们查阅文献，获取有关使用降尿酸疗法对痛风进行慢性管理的女性痛风患者的治疗结果数据，以及用于急性发作的常用药物的数据。我们还讨论了孕期和哺乳期女性痛风管理的注意事项。
