[多病共存老年患者的多重用药与不适当用药——OPERAM研究带给我们的启示及未来的启示]

[Polypharmacy and inappropriate medications in multimorbid elderly patients - What OPERAM taught us and will teach us].

作者信息

Bretagne Lisa, Tabea Jungo Katharina, Blum Manuel R, Schwenkglenks Matthias, Chiolero Arnaud, Del Giovane Cinzia, Gencer Baris, Aujesky Drahomir, Rodondi Nicolas

机构信息

Département de médecine interne générale, Inselspital, Hôpital universitaire de Berne et Université de Berne, 3010 Berne.

Institut bernois de médecine de famille (BIHAM), Université de Berne, 3012 Berne.

出版信息

Rev Med Suisse. 2022 Mar 9;18(772):427-432. doi: 10.53738/REVMED.2022.18.772.427.

DOI:10.53738/REVMED.2022.18.772.427

PMID:35266342

Abstract

Polypharmacy and inappropriate medication use are very common in multimorbid older patients. This population has unfortunately been excluded from most large, randomized studies. In a recent multicenter randomized study (OPERAM), we included over 2000 multimorbid patients. We found that 86% of the patients aged 70 years and more had inappropriate medications and that these medications could be discontinued without negative impact on the health of these patients. This cohort of multimorbid patients will be followed for 10 years to evaluate their prognosis, life expectancy, treatments and quality of life, with numerous projects to better understand the inappropriate prescribing of individual drugs and their consequences on the health of this population.

摘要

多重用药和不适当用药在患有多种疾病的老年患者中非常普遍。不幸的是，这一人群被排除在大多数大型随机研究之外。在最近一项多中心随机研究（OPERAM）中，我们纳入了2000多名患有多种疾病的患者。我们发现，70岁及以上的患者中有86%存在不适当用药情况，而且停用这些药物不会对这些患者的健康产生负面影响。这组患有多种疾病的患者将被随访10年，以评估他们的预后、预期寿命、治疗情况和生活质量，还有众多项目来更好地了解个别药物的不适当处方及其对这一人群健康的影响。