[表没食子儿茶素-3-没食子酸酯抗感染特性的研究进展]

[Progress of researches on anti-infective properties of epigallocatechin-3-gallate].

作者信息

Du W Q, Xue T

机构信息

Department of Medical Laboratory, the 11th Clinical Medical College, Shanxi Medical University, Lüliang, Shanxi 033000, China.

National Health Commission Key Laboratory of Pneumoconiosis, Department of Respiratory and Critical Medicine, the First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China.

出版信息

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2021 Dec 13;34(1):102-108. doi: 10.16250/j.32.1374.2021101.

DOI:10.16250/j.32.1374.2021101

PMID:35266367

Abstract

(-)-epigallocatechin-3-O-gallate (EGCG) is the most abundant polyphenol in green tea, which has shown anti-oxidant, anti-inflammatory, anti-thrombotic, anti-radiation, anti-mutant, anti-cancer and anti-fibrotic actions, and has shown improvements of diabetes, obesity, asthma, cancer, cardiovascular diseases and central nervous system disorders. In addition, EGCG is reported to enhance the human immunity. Recently, EGCG has been found to play a vital role in infectious diseases caused by pathogenic microorganisms, including bacteria, fungi, viruses and parasites. The review summarizes the progress of researches on anti-infective properties of EGCG, so as to elucidate the potential role of EGCG in the prevention and treatment of infectious diseases.

摘要

（-）-表没食子儿茶素-3-O-没食子酸酯（EGCG）是绿茶中含量最丰富的多酚，它具有抗氧化、抗炎、抗血栓形成、抗辐射、抗突变、抗癌和抗纤维化作用，并且已显示出对糖尿病、肥胖症、哮喘、癌症、心血管疾病和中枢神经系统疾病有改善作用。此外，据报道EGCG可增强人体免疫力。最近，已发现EGCG在由致病微生物（包括细菌、真菌、病毒和寄生虫）引起的传染病中发挥重要作用。本文综述了EGCG抗感染特性的研究进展，以阐明EGCG在传染病预防和治疗中的潜在作用。