Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Indonesia.
Department of Anesthesiology and Intensive Care, Tangerang District Hospital, Indonesia.
Anaesthesiol Intensive Ther. 2022;54(1):42-47. doi: 10.5114/ait.2022.113750.
Postoperative pain following lower abdominal surgery is one of the most common complications reported by patients. Gabapentin given two hours before surgery as pre-emptive analgesia has been reported to reduce postoperative pain and decrease postoperative analgesia requirements. The aim of this study was to determine the effectiveness of 600 mg oral gabapentin as a pre-emptive analgesia to reduce postoperative pain and morphine requirements following nonobstetric lower abdominal surgery.
A double-blind randomized clinical trial was conducted with 72 subjects acquired by consecutive sampling from November 2019 to February 2020 at Tangerang District Hospital. Eligible subjects were randomized to two groups: placebo or 600 mg oral gabapentin two hours before skin incision. The total morphine requirements, visual analogue scale (VAS) score, first-time analgesic demand, and side effects were assessed during the first 24 hours postoperatively.
The first 24-hour postoperative total morphine was higher in the placebo group (5.33 ± 1.97 mg vs. 2.47 ± 1.90 mg; P < 0.001). The pain scale at rest and movement during recovery, two hours postoperatively, and 24 hours postoperatively were significantly different between the two groups (P < 0.05). The Mann-Whitney test showed a significant difference in the first-time morphine required as rescue analgesia between the gabapentin group (161.5 [25-990] minutes) and placebo group (67.5 [10-371] minutes; P < 0.001). No significant difference was found in adverse events between the groups.
Following nonobstetric lower abdominal surgery, 600 mg oral gabapentin as a pre-emptive analgesia attenuates postoperative pain and reduces morphine requirements.
下腹部手术后的疼痛是患者最常见的并发症之一。术前两小时给予加巴喷丁作为预防性镇痛，已被报道可减轻术后疼痛和减少术后镇痛需求。本研究旨在确定 600mg 口服加巴喷丁作为预防性镇痛，以减少非产科下腹部手术后的术后疼痛和吗啡需求。
这是一项双盲随机临床试验，于 2019 年 11 月至 2020 年 2 月在万隆区医院连续抽样获得 72 名受试者。合格的受试者被随机分为两组：安慰剂或术前两小时口服 600mg 加巴喷丁。在术后 24 小时内评估总吗啡需求量、视觉模拟评分（VAS）评分、首次镇痛需求和副作用。
术后 24 小时内，安慰剂组的总吗啡用量（5.33 ± 1.97mg 比 2.47 ± 1.90mg；P < 0.001）较高。两组在恢复时的静息和运动疼痛评分、术后两小时和 24 小时均有显著差异（P < 0.05）。曼-惠特尼检验显示，加巴喷丁组（161.5 [25-990] 分钟）和安慰剂组（67.5 [10-371] 分钟）首次需要吗啡作为解救性镇痛的时间有显著差异（P < 0.001）。两组不良反应无显著差异。
在下腹部非产科手术后，600mg 口服加巴喷丁作为预防性镇痛可减轻术后疼痛并减少吗啡需求。
