Laboratory of Food Science and Human Health, College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong 266003, China.
Laboratory of Animal Genomics and Improvement, United States Department of Agriculture, Agriculture Research Service (USDA-ARS), Beltsville, MD 20705, USA.
Food Funct. 2022 Mar 21;13(6):3720-3731. doi: 10.1039/d1fo03185f.
Emulsion-based delivery systems have been reported to improve the solubility, stability and bioavailability of astaxanthin. In this study, the ability of astaxanthin-loaded emulsions (AL) to ameliorate obesity induced by a high-fat and high-sucrose diet was explored, using astaxanthin in the oil phase (ASTA) as a comparison. After the administration of AL, ASTA (30 mg per kg body weight), or saline on normal or obese mice for 4 weeks, the body fat accumulation levels, hepatic lipid contents and hepatic fatty acid profiles were detected, and AL showed better anti-obesity properties than ASTA. In an acute feeding experiment, it was first observed that the astaxanthin concentration of AL was higher than that of ASTA in the blood and liver of obese mice. What's more, AL altered the microbial co-occurrence patterns in obese mice. Some gut microbial modules that were significantly correlated with obesity-related physiological parameters were identified. Overall, the improvement effect of AL on obesity is better than that of ASTA due to their higher oral absorbability and modulating effects on the gut microbiota, and we suggest AL as a more suitable astaxanthin product type for obese bodies.
乳液递送系统已被报道可以提高虾青素的溶解度、稳定性和生物利用度。在这项研究中，通过使用油相中的虾青素（ASTA）作为对照，探索了负载虾青素的乳液（AL）改善高脂肪高蔗糖饮食诱导肥胖的能力。在正常或肥胖小鼠上施用 AL、ASTA（每公斤体重 30 毫克）或生理盐水 4 周后，检测体脂积累水平、肝脂质含量和肝脂肪酸谱，结果表明 AL 具有比 ASTA 更好的抗肥胖特性。在急性喂养实验中，首先观察到在肥胖小鼠的血液和肝脏中，AL 中的虾青素浓度高于 ASTA。此外，AL 改变了肥胖小鼠肠道微生物的共现模式。确定了一些与肥胖相关生理参数显著相关的肠道微生物模块。总的来说，由于 AL 具有更高的口服吸收性和对肠道微生物群的调节作用，其对肥胖的改善效果优于 ASTA，我们建议将 AL 作为肥胖人群更合适的虾青素产品类型。
