• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在分化阶段添加前列腺素D2及其类似物11d-11m-PGD2，有助于抑制3T3-L1细胞中的脂肪生成程序。

Prostaglandin D2 and its analog, 11d-11m-PGD2, added during the differentiation phase contribute to adipogenic program inhibition in 3T3-L1 cells.

作者信息

Nartey Michael N N, Jisaka Mitsuo, Syeda Pinky Karim, Nishimura Kohji, Shimizu Hidehisa, Yokota Kazushige

机构信息

The United Graduate School of Agricultural Sciences, Tottori University, 4-101 Koyama-Minami, Tottori, Japan.

Council for Scientific and Industrial Research-Animal Research Institute, Achimota, Accra, Ghana.

出版信息

Biosci Biotechnol Biochem. 2022 Apr 21;86(5):628-634. doi: 10.1093/bbb/zbac035.

DOI:10.1093/bbb/zbac035
PMID:35266506
Abstract

We previously reported that prostaglandin (PG)D2 and its isosteric analog, 11-deoxy-11-methylene-PGD2 (11d-11m-PGD2), promote adipogenesis in 3T3-L1 cells during the maturation phase. Focusing on the differentiation phase, although both PGs inhibited adipogenesis, this effect was canceled out by PGI2 and PGJ2 derivatives. Thus, PGD2 and 11d-11m-PGD2 play different roles during the phases, but do not affect PGI2- and PGJ2-derivative-induced adipogenesis.

摘要

我们之前报道过，前列腺素（PG）D2及其等排类似物11-脱氧-11-亚甲基-PGD2（11d-11m-PGD2）在成熟阶段促进3T3-L1细胞的脂肪生成。着眼于分化阶段，尽管这两种前列腺素均抑制脂肪生成，但这种作用被前列环素（PGI2）和PGJ2衍生物抵消。因此，PGD2和11d-11m-PGD2在各阶段发挥不同作用，但不影响PGI2和PGJ2衍生物诱导的脂肪生成。

相似文献

1
Prostaglandin D2 and its analog, 11d-11m-PGD2, added during the differentiation phase contribute to adipogenic program inhibition in 3T3-L1 cells.在分化阶段添加前列腺素D2及其类似物11d-11m-PGD2，有助于抑制3T3-L1细胞中的脂肪生成程序。
Biosci Biotechnol Biochem. 2022 Apr 21;86(5):628-634. doi: 10.1093/bbb/zbac035.
2
Comparison of pro-adipogenic effects between prostaglandin (PG) D and its stable, isosteric analogue, 11-deoxy-11-methylene-PGD, during the maturation phase of cultured adipocytes.前列腺素（PG）D与其稳定的等排类似物11-脱氧-11-亚甲基-PGD在培养脂肪细胞成熟阶段的促脂肪生成作用比较。
Prostaglandins Other Lipid Mediat. 2018 Nov;139:71-79. doi: 10.1016/j.prostaglandins.2018.10.006. Epub 2018 Oct 26.
3
Prostaglandin D Added during the Differentiation of 3T3-L1 Cells Suppresses Adipogenesis via Dysfunction of D-Prostanoid Receptor P1 and P2.在3T3-L1细胞分化过程中添加前列腺素D通过D-前列腺素受体P1和P2功能障碍抑制脂肪生成。
Life (Basel). 2023 Jan 29;13(2):370. doi: 10.3390/life13020370.
4
Retraction to: Prostaglandin D2 and its analog, 11d-11m-PGD2, added during the differentiation phase contribute to adipogenic program inhibition in 3T3-L1 cells.撤回至：在分化阶段添加前列腺素D2及其类似物11d - 11m - PGD2有助于抑制3T3 - L1细胞中的脂肪生成程序。
Biosci Biotechnol Biochem. 2023 Jan 24;87(2):245. doi: 10.1093/bbb/zbac196.
5
Arachidonic Acid Added during the Differentiation Phase of 3T3-L1 Cells Exerts Anti-Adipogenic Effect by Reducing the Effects of Pro-Adipogenic Prostaglandins.在3T3-L1细胞分化阶段添加花生四烯酸通过降低促脂肪生成前列腺素的作用发挥抗脂肪生成效应。
Life (Basel). 2023 Jan 29;13(2):367. doi: 10.3390/life13020367.
6
15-Deoxy-Δ(12,14)-prostaglandin J(2) interferes inducible synthesis of prostaglandins E(2) and F(2α) that suppress subsequent adipogenesis program in cultured preadipocytes.15-脱氧-Δ(12,14)-前列腺素 J(2) 干扰诱导型前列腺素 E(2) 和 F(2α) 的合成，从而抑制培养前体脂肪细胞中的后续脂肪生成程序。
Prostaglandins Other Lipid Mediat. 2011 Aug;95(1-4):53-62. doi: 10.1016/j.prostaglandins.2011.06.002. Epub 2011 Jun 12.
7
Prostaglandin D and F as Regulators of Adipogenesis and Obesity.前列腺素 D 和 F 作为脂肪生成和肥胖的调节剂。
Biol Pharm Bull. 2022;45(8):985-991. doi: 10.1248/bpb.b22-00210.
8
Prostaglandin D2 inhibits inducible nitric oxide synthase expression in rat vascular smooth muscle cells.前列腺素D2抑制大鼠血管平滑肌细胞中诱导型一氧化氮合酶的表达。
Circ Res. 1998 Feb 9;82(2):204-9. doi: 10.1161/01.res.82.2.204.
9
Mast cells function as an alternative modulator of adipogenesis through 15-deoxy-delta-12, 14-prostaglandin J2.肥大细胞通过 15-脱氧-δ-12,14-前列腺素 J2 作为脂肪生成的另一种调节剂发挥作用。
Am J Physiol Cell Physiol. 2011 Dec;301(6):C1360-7. doi: 10.1152/ajpcell.00514.2010. Epub 2011 Aug 24.
10
Cultured preadipocytes undergoing stable transfection with cyclooxygenase-1 in the antisense direction accelerate adipogenesis during the maturation phase of adipocytes.经环氧化酶-1 反义稳定转染的培养前脂肪细胞在脂肪细胞成熟阶段加速脂肪生成。
Appl Biochem Biotechnol. 2013 Sep;171(1):128-44. doi: 10.1007/s12010-013-0347-3. Epub 2013 Jul 2.