Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
Org Biomol Chem. 2022 Mar 30;20(13):2544-2561. doi: 10.1039/d2ob00054g.
The asymmetric Mannich reaction is an essential method in contemporary organic chemistry. As a representative of clean and green synthesis methods, photochemical and electrochemical oxidation strategies have re-emerged in recent years, providing new ideas for asymmetric Mannich reactions. Numerous chiral -amino carbonyl compounds have been accessed in satisfactory yields with excellent enantioselectivity such novel asymmetric oxidative Mannich reactions. This minireview highlights plentiful advances in asymmetric oxidative Mannich reactions that rely on photoredox or anodic-oxidation and covers the literature from 2014 to date. Furthermore, the future development of this field is envisaged.
不对称 Mannich 反应是当代有机化学中的一种重要方法。作为清洁绿色合成方法的代表，光化学和电化学氧化策略近年来重新出现，为不对称 Mannich 反应提供了新的思路。许多手性 - 氨基羰基化合物已经以令人满意的收率和优异的对映选择性得到，例如新颖的不对称氧化 Mannich 反应。这篇综述重点介绍了依赖于光氧化还原或阳极氧化的不对称氧化 Mannich 反应的大量进展，并涵盖了自 2014 年以来的文献。此外，还展望了该领域的未来发展。
