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1318纳米二极管激光在肝脏开放手术中的评估

The Evaluation of the 1318 nm Diode Laser in Open Liver Surgery.

作者信息

Pfitzmaier Patrick, Schwarzbach Matthias, Ronellenfitsch Ulrich

机构信息

Department of General, Visceral, Vascular and Thoracic Surgery, Klinikum Frankfurt Höchst, Gotenstraße 6-8, 65929 Frankfurt, Germany.

Department of Visceral, Vascular and Endocrine Surgery, University Hospital Halle (Saale), Martin-Luther-University Halle-Wittenberg, 06120 Halle, Germany.

出版信息

Cancers (Basel). 2022 Feb 25;14(5):1191. doi: 10.3390/cancers14051191.

Abstract

(1) Background: Numerous dissection instruments are available for liver resection. So far, there has been no evidence in favor of a specific dissection device effecting a reduction in postoperative mortality and morbidity or a reduction in intraoperative blood loss. The aim of the study was to evaluate the safety of liver resection with the 1318 nm surgical laser. (2) Methods: 151 consecutive patients who underwent liver resection using the 1318 nm surgical laser ( = 119) or conventional dissection methods ( = 32) were evaluated retrospectively. As primary outcome, postoperative complications were assessed using the Clavien-Dindo classification. Secondary outcomes were postoperative mortality, reoperations and reinterventions, intraoperative blood loss, the need for vascular control using the Pringle maneuver and oncological safety assessed through histopathological evaluation of resection margins. (3) Results: For liver resections using the 1318 nm surgical laser, the postoperative morbidity (41.2% vs. 59.4%, = 0.066), mortality (1.7% vs. 3.1%, = 0.513) and the reoperation rate (2.5% vs. 3.1%, = 1.000) were not significantly different from conventional liver resections. In the laser group, a lower reintervention rate (9.2% vs. 21.9%, = 0.050) was observed. The oncological safety demonstrated by a tumor-free resection margin was similar after laser and conventional resection (93.2% vs. 89.3%, = 0.256). The median intraoperative blood loss was significantly lower in the laser group (300 mL vs. 500 mL, = 0.005) and there was a significantly lower need for a Pringle maneuver (3.4% vs. 15.6%, = 0.021). (4) Conclusions: Liver resections using the 1318 nm surgical laser can be routinely performed with a favorable risk profile. Compared to alternative resection methods, they are associated with low blood loss, appear adequate from an oncological point of view, and are not associated with increased mortality and morbidity.

摘要

(1) 背景:有多种解剖器械可用于肝切除术。到目前为止,尚无证据表明特定的解剖器械能降低术后死亡率和发病率或减少术中失血。本研究的目的是评估使用1318纳米外科激光进行肝切除术的安全性。(2) 方法:对151例连续接受肝切除术的患者进行回顾性评估,其中119例使用1318纳米外科激光,32例采用传统解剖方法。作为主要结局,使用Clavien-Dindo分类法评估术后并发症。次要结局包括术后死亡率、再次手术和再次干预、术中失血、使用Pringle手法控制血管的需求以及通过切缘组织病理学评估的肿瘤学安全性。(3) 结果:对于使用1318纳米外科激光进行的肝切除术,术后发病率(41.2% 对59.4%,P = 0.066)、死亡率(1.7% 对3.1%,P = 0.513)和再次手术率(2.5% 对3.1%,P = 1.000)与传统肝切除术无显著差异。在激光组中,观察到再次干预率较低(9.2% 对21.9%,P = 0.050)。激光切除和传统切除后切缘无肿瘤所显示的肿瘤学安全性相似(93.2% 对89.3%,P = 0.256)。激光组术中失血量中位数显著更低(300毫升对500毫升,P = 0.005),且使用Pringle手法的需求显著更低(3.4% 对15.6%,P = 0.021)。(4) 结论:使用1318纳米外科激光进行肝切除术可常规进行,风险状况良好。与其他切除方法相比,它们与低失血量相关,从肿瘤学角度看似乎足够,且与死亡率和发病率增加无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9716/8909064/ac57bf95af33/cancers-14-01191-g001.jpg

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