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红肉苹果富含花色苷，而白肉苹果可调节高胆固醇血症大鼠的主动脉和心脏蛋白质组：AppleCOR 研究。

Red-Fleshed Apples Rich in Anthocyanins and White-Fleshed Apples Modulate the Aorta and Heart Proteome in Hypercholesterolaemic Rats: The AppleCOR Study.

机构信息

Functional Nutrition, Oxidation, and CVD Research Group (NFOC-Salut), Medicine and Surgery Department, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, 43201 Reus, Spain.

Institut d'Investigació Sanitària Pere Virgili (IISPV), 43204 Reus, Spain.

出版信息

Nutrients. 2022 Feb 28;14(5):1047. doi: 10.3390/nu14051047.

DOI:10.3390/nu14051047
PMID:35268023
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8912372/
Abstract

The impact of a red-fleshed apple (RFA) rich in anthocyanins (ACNs), a white-fleshed apple (WFA) without ACNs, and an extract infusion from fruit (AI) equivalent in dose of cyanidin-3-O-galactoside (main ACN) as RFA was determined by the proteome profile of aorta and heart as key cardiovascular tissues. Hypercholesterolaemic Wistar rats were separated into six groups ( = 6/group; three males and three females) and the proteomic profiles were analyzed using nanoliquid chromatography coupled to mass spectrometry. No adverse events were reported and all products were well tolerated. RFA downregulated C1QB and CFP in aorta and CRP in heart. WFA downregulated C1QB and CFP in aorta and C9 and C3 in aorta and heart, among other proteins. AI downregulated PRKACA, IQGAP1, and HSP90AB1 related to cellular signaling. Thus, both apples showed an anti-inflammatory effect through the complement system, while RFA reduced CRP. Regardless of the ACN content, an apple matrix effect was observed that involved different bioactive components, and inflammatory proteins were reduced.

摘要

采用主动脉和心脏作为关键心血管组织，通过蛋白质组图谱来测定富含花色苷（ACN）的红肉苹果（RFA）、不含 ACN 的白肉苹果（WFA）和剂量相当的来自果实的提取浸膏（AI）的作用。将高胆固醇血症 Wistar 大鼠分为六组（每组 6 只，雄性和雌性各 3 只），并使用纳升液相色谱与质谱联用分析蛋白质组图谱。未报告不良事件，所有产品均耐受良好。RFA 下调主动脉中的 C1QB 和 CFP 以及心脏中的 CRP。WFA 下调主动脉中的 C1QB 和 CFP 以及主动脉和心脏中的 C9 和 C3 以及其他蛋白质。AI 下调与细胞信号相关的 PRKACA、IQGAP1 和 HSP90AB1。因此，两种苹果均通过补体系统表现出抗炎作用，而 RFA 则降低 CRP。无论 ACN 含量如何，均观察到苹果基质效应，其中涉及不同的生物活性成分，且炎症蛋白减少。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcf9/8912372/8ca8c14e82a6/nutrients-14-01047-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcf9/8912372/8cbfbd982e2a/nutrients-14-01047-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcf9/8912372/9e4d2c17ac93/nutrients-14-01047-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcf9/8912372/8ca8c14e82a6/nutrients-14-01047-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcf9/8912372/8cbfbd982e2a/nutrients-14-01047-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcf9/8912372/9e4d2c17ac93/nutrients-14-01047-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcf9/8912372/8ca8c14e82a6/nutrients-14-01047-g003.jpg

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