Wu Yuqing, Jiang Hao, Zhou Xujiao, Zhai Zimeng, Yang Pei, Zhou Shuyun, Gu Hao, Xu Jianjiang, Hong Jiaxu
Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200031, China.
Department of Ophthalmology, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.
J Clin Med. 2022 Mar 4;11(5):1427. doi: 10.3390/jcm11051427.
Allergic conjunctivitis (AC) is one of the most common ocular disorders in clinical practice and is associated with meibomian gland dysfunction. This study aimed to explore the morphological and functional changes of meibomian glands (MGs) in pediatric and adult patients with AC and to analyze their potential predictors. In our prospective, observational cohort study, a total of 59 patients with AC were enrolled, with 30 patients aged ≤16 years in the pediatric group and 29 patients in the adult group. All patients underwent examinations at baseline and last visit when the complete resolution of conjunctival papillae was identified. An automatic MG analyzer was used to measure the morphological and functional parameters of MGs, including their area ratio (GA), tortuosity index (TI), and signal index (SI). Two groups were comparable at baseline in terms of characteristics and MG parameters (p > 0.05). The morphological (length, square, and GA) and functional MG parameters (SI) of AC patients significantly improved in the pediatric group after treatment (all p < 0.05), but not in the adult group. The change in the GA correlated with age, sex, GA, TI, and SI at baseline (all p < 0.05). Age (p = 0.001) and GA (p < 0.001) at baseline were predictors of an improvement in the GA of MGs. The findings showed that the structure and function of MGs in pediatric patients with AC seem to improve after the conjunctival papillae disappear, but not in adult patients.
过敏性结膜炎（AC）是临床实践中最常见的眼部疾病之一，与睑板腺功能障碍有关。本研究旨在探讨儿童和成人AC患者睑板腺（MGs）的形态和功能变化，并分析其潜在预测因素。在我们的前瞻性观察队列研究中，共纳入59例AC患者，其中儿童组30例年龄≤16岁，成人组29例。所有患者在基线和最后一次就诊时进行检查，此时结膜乳头已完全消退。使用自动MG分析仪测量MGs的形态和功能参数，包括面积比（GA）、弯曲指数（TI）和信号指数（SI）。两组在基线时的特征和MG参数方面具有可比性（p>0.05）。治疗后，儿童组AC患者的MGs形态（长度、面积和GA）和功能参数（SI）显著改善（均p<0.05），而成人组未改善。GA的变化与基线时的年龄、性别、GA、TI和SI相关（均p<0.05）。基线时的年龄（p=0.001）和GA（p<0.001）是MGs的GA改善的预测因素。研究结果表明，儿童AC患者结膜乳头消失后MGs的结构和功能似乎有所改善，而成人患者则不然。
