次氯酸通过超声雾化对睑缘炎的影响：一项随机临床试验。
Effect of Hypochlorous Acid on Blepharitis through Ultrasonic Atomization: A Randomized Clinical Trial.
作者信息
Zhang Hong, Wu Yuqing, Wan Xichen, Shen Yan, Le Qihua, Yang Pei, Zhou Shuyun, Zhou Xujiao, Zhou Feng, Gu Hao, Hong Jiaxu
机构信息
Department of Ophthalmology, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.
Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200437, China.
出版信息
J Clin Med. 2023 Feb 1;12(3):1164. doi: 10.3390/jcm12031164.
PURPOSE
To evaluate the efficacy and safety of eyelid hygiene using topical 0.01% hypochlorous acid (HOCL) through ultrasonic atomization after 2 weeks in patients with blepharitis.
DESIGN
Randomized controlled trial.
METHODS
Patients with blepharitis were randomized into two groups: topical 0.01% HOCL through ultrasonic atomization (HOCL group, 42 eyes) or eyelid scrubs (control group, 37 eyes). Patients in both groups received warm compresses twice daily and topical 0.5% levofloxacin three times a day. Primary outcomes were the ocular surface disease index scores (OSDI), lid margin redness, lid margin abnormalities, meibum expressibility, meibum quality, and noninvasive breakup time after 2 weeks. Secondary outcomes were conjunctiva redness, corneal fluorescein staining, and tear meniscus height. A questionnaire of treatment adherence with a free response section was administered to confirm patient compliance and comments.
RESULTS
Sixty-seven participants participated in this study. Both groups show an improvement in all primary outcomes, while statistically significant improvements in OSDI, lid margin redness, lid margin abnormality, meibum expressibility and quality are only limited to the HOCL group after 2 weeks of treatment ( < 0.05, < 0.05, < 0.001, < 0.001 and < 0.001, respectively). Subgroup analysis in HOCL reveals that only the change in lid margin abnormality and meibum expressibility in the mild-moderate meibomian glands loss patients at baseline has a statistically significant difference < 0.05). Multiple linear regression shows that the improvement in OSDI is negatively associated with meibum expressibility score at the baseline (95% CI [-28.846, -1.815], = 0.028). The patient compliance is 7.1 ± 2.0 in the HOCL group and 7.1 ± 1.8 in the control group ( > 0.05). No adverse events are reported.
CONCLUSION
Topical 0.01% HOCL through ultrasonic atomization is a tolerable and effective eyelid hygiene treatment for blepharitis.
目的
评估睑缘炎患者使用0.01%次氯酸（HOCL）超声雾化进行睑缘清洁2周后的疗效和安全性。
设计
随机对照试验。
方法
睑缘炎患者被随机分为两组：0.01% HOCL超声雾化组（HOCL组，42只眼）和睑缘擦洗组（对照组，37只眼）。两组患者均每天进行2次热敷，并每天3次局部使用0.5%左氧氟沙星。主要观察指标为2周后的眼表疾病指数评分（OSDI）、睑缘发红、睑缘异常、睑板腺分泌物排出情况、睑板腺分泌物质量和非侵入性泪膜破裂时间。次要观察指标为结膜充血、角膜荧光素染色和泪河高度。通过一份带有自由回答部分的治疗依从性问卷来确认患者的依从性和意见。
结果
67名参与者参与了本研究。两组所有主要观察指标均有改善，但治疗2周后，HOCL组在OSDI、睑缘发红、睑缘异常、睑板腺分泌物排出情况和质量方面的改善具有统计学意义（分别为P<0.05、P<0.05、P<0.001、P<0.001和P<0.001）。HOCL组的亚组分析显示，仅基线时轻度至中度睑板腺功能障碍患者的睑缘异常和睑板腺分泌物排出情况的变化具有统计学意义（P<0.05）。多元线性回归显示，基线时OSDI的改善与睑板腺分泌物排出情况评分呈负相关（95%CI[-28.846，-1.815]，P=0.028）。HOCL组患者依从性为7.1±2.0，对照组为7.1±1.8（P>0.05）。未报告不良事件。
结论
0.01% HOCL超声雾化是一种可耐受且有效的睑缘炎睑缘清洁治疗方法。
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