Key Laboratory of Lymphatic Surgery Jilin Province, Jilin Engineering Laboratory for Lymphatic Surgery Jilin Province, China-Japan Union Hospital of Jilin University, Changchun 130031, China.
Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education and Faculty of Chemistry, Northeast Normal University, Changchun 130024, China.
Molecules. 2022 Feb 25;27(5):1558. doi: 10.3390/molecules27051558.
Porous organic polymers have an open architecture, excellent stability, and tunable structural components, revealing great application potential in the field of fluorescence imaging, but this part of the research is still in its infancy. In this study, we aimed to tailor the physical and chemical characteristics of indocyanine green using sulfonic acid groups and conjugated fragments, and prepared amino-grafted porous polymers. The resulting material had excellent solvent and thermal stability, and possessed a relatively large pore structure with a size of 3.4 nm. Based on the synergistic effect of electrostatic bonding and π-π interactions, the fluorescent chromogenic agent, indocyanine green, was tightly incorporated into the pore cavity of POP solids through a one-step immersion method. Accordingly, the fluorescent chromogenic POP demonstrated excellent imaging capabilities in biological experiments. This preparation of fluorescent chromogenic porous organic polymer illustrates a promising application of POP-based solids in both fluorescence imaging and biomedicine applications.
多孔有机聚合物具有开放的架构、优异的稳定性和可调节的结构组成部分，在荧光成像领域显示出巨大的应用潜力，但这部分研究仍处于起步阶段。在这项研究中，我们旨在通过磺酸基团和共轭片段来调整吲哚菁绿的物理和化学特性，并制备氨基接枝多孔聚合物。所得材料具有优异的溶剂和热稳定性，并且具有相对较大的孔结构，尺寸为 3.4nm。基于静电键合和 π-π 相互作用的协同效应，荧光显色剂吲哚菁绿通过一步浸渍法被紧密地纳入 POP 固体的孔腔中。因此，荧光显色 POP 在生物实验中表现出优异的成像能力。这种荧光显色多孔有机聚合物的制备说明了基于 POP 的固体在荧光成像和生物医学应用中的有前途的应用。
