重组DNA衍生的甲硫氨酰人生长激素的20000道尔顿结构变体在垂体切除的大鼠中具有早期胰岛素样作用。
The 20,000 dalton structural variant of recombinant DNA-derived methionyl human growth hormone has early insulin-like effects in hypophysectomized rats.
作者信息
Tinsley F C, Grinnan E L, Baker S H, Powell J G, Bemis K G, Shaar C J
出版信息
Biochem Biophys Res Commun. 1986 Jul 16;138(1):342-8. doi: 10.1016/0006-291x(86)90286-x.
The 20,000 dalton variant of recombinant DNA-derived methionyl human growth hormone (20K-Met-hGH) induced decreases in blood glucose and free fatty acid concentrations one hour after intraperitoneal injection into fasted, hypophysectomized rats. Similar results were obtained using the 22,000 dalton form of recombinant DNA-derived methionyl human growth hormone (22K-Met-hGH). The data reported show that 20K-Met-hGH induces early insulin-like effects similar to the responses produced by 22K-Met-hGH in fasted hypophysectomized rats.
将重组DNA衍生的甲硫氨酰人生长激素的20,000道尔顿变体（20K-甲硫氨酰-hGH）腹腔注射到禁食、垂体切除的大鼠体内一小时后，血糖和游离脂肪酸浓度降低。使用重组DNA衍生的甲硫氨酰人生长激素的22,000道尔顿形式（22K-甲硫氨酰-hGH）也得到了类似结果。所报道的数据表明，在禁食、垂体切除的大鼠中，20K-甲硫氨酰-hGH诱导出与22K-甲硫氨酰-hGH产生的反应相似的早期胰岛素样作用。
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