链脲佐菌素诱导的糖尿病及胰岛素治疗对大鼠骨骼肌中己糖激酶II降解的影响。

Effect of streptozotocin-induced diabetes and insulin treatment on the degradation of hexokinase II in the skeletal muscle of the rat.

作者信息

Frank S K, Fromm H J

出版信息

Biochem Biophys Res Commun. 1986 Jul 16;138(1):374-80. doi: 10.1016/0006-291x(86)90291-3.

Abstract

The rate of degradation of hexokinase II and the general pool of cytosolic proteins was measured in the skeletal muscle of normal, streptozotocin-diabetic, and insulin-treated streptozotocin-diabetic rats. The rate constant for hexokinase II degradation increases by a factor of 3 in the diabetic as compared with the normal animal. There were analogous alterations observed for the general pool of cytosolic proteins; however, the changes were much more subtle. Insulin treatment restores the increased degradative rate to normal levels in both classes of muscle proteins.

摘要

在正常大鼠、链脲佐菌素诱导的糖尿病大鼠以及胰岛素治疗的链脲佐菌素诱导的糖尿病大鼠的骨骼肌中，测定了己糖激酶II和胞质蛋白总库的降解速率。与正常动物相比，糖尿病大鼠中己糖激酶II降解的速率常数增加了3倍。在胞质蛋白总库中也观察到了类似的变化；然而，这些变化更为细微。胰岛素治疗可使两类肌肉蛋白增加的降解速率恢复到正常水平。