Lee Byeong Jun, Park Joon Seong, Kim Hyung Sun, Yoon Dong Sup, Lim Jin Hong
Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Ann Hepatobiliary Pancreat Surg. 2022 Aug 31;26(3):244-250. doi: 10.14701/ahbps.21-152. Epub 2022 Mar 11.
BACKGROUNDS/AIMS: Early recovery after surgery has become a popular trend. The aim of this study was to evaluate effect of nutritional intervention using Encover, an oral nutritional supplement, in patients undergoing hepato-biliary-pancreatic surgery.
This single center, prospective case-control study was conducted in Gangnam Severance Hospital from September 2018 to April 2019. Through randomization, patients were divided into an experimental group (30 patients) and a control group (30 patients). At postoperative seven days, the experimental group was instructed to take two packs of Encover (JW Pharmaceutical, Seoul, Korea) daily for seven days. Body cell mass index was measured at seven days after surgery and 14 days after discharge and Patient-Generated Subjective Global Assessment (PG-SGA) was performed at 14 days after discharge.
Body cell mass index during outpatient follow-up was significantly decreased compared to that at discharge in both groups. However, the amount of body cell mass index showed no significant difference between postoperative seven days and outpatient follow- up in either group. During outpatient follow-up, the experimental group had a higher mean value of PG-SGA score than the control group (11.32 ± 3.46 vs. 9.48 ± 3.97; = 0.037).
Short-term Encover doses after surgery may not produce significant results in weight gain or other body cell mass index. Encover did not significantly affect other dietary conditions based on PG-SGA.
背景/目的：术后早期恢复已成为一种流行趋势。本研究旨在评估使用口服营养补充剂安素（Encover）进行营养干预对肝胆胰手术患者的影响。
本单中心前瞻性病例对照研究于2018年9月至2019年4月在江南Severance医院进行。通过随机分组，患者被分为实验组（30例）和对照组（30例）。术后第7天，指导实验组患者每天服用两包安素（韩国首尔JW制药公司生产），持续7天。在术后7天和出院后14天测量身体细胞质量指数，并在出院后14天进行患者主观整体评定法（PG-SGA）评估。
两组门诊随访期间的身体细胞质量指数均较出院时显著降低。然而，两组术后7天与门诊随访期间身体细胞质量指数的下降幅度均无显著差异。门诊随访期间，实验组的PG-SGA评分平均值高于对照组（11.32±3.46对9.48±3.97；P = 0.037）。
术后短期服用安素可能不会在体重增加或其他身体细胞质量指数方面产生显著效果。基于PG-SGA，安素对其他饮食状况没有显著影响。
