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一种使用 3D 打印体模进行剂量学和几何治疗验证的端到端新测试。

A novel end-to-end test for combined dosimetric and geometric treatment verification using a 3D-printed phantom.

机构信息

Department of Radiation Oncology, University Medical Centre Mannheim, University of Heidelberg, 68167, Mannheim, Germany.

Department of Radiation Oncology, University Medical Centre Mannheim, University of Heidelberg, 68167, Mannheim, Germany.

出版信息

Med Dosim. 2022;47(2):177-183. doi: 10.1016/j.meddos.2022.02.002. Epub 2022 Mar 7.

Abstract

The dosimetric and geometric accuracy are important components to ensure safe patient treatment in radiation therapy. Therefore, these components must be checked during quality control. This work presents a possible solution for the determination of the geometric isocenter deviation in the entire treatment chain. Additionally, the dose measurement of the established end-to-end test workflow measured in the same procedure as the geometric deviation is described. An in-house designed end-to-end test phantom went through the entire procedure of a standard patient treatment and the dosimetric and geometric accuracy were determined. At 3 linear accelerators (linac), the phantom was positioned either with cone beam computed tomography or with surface guidance. In this position, a Winston-Lutz test was performed and the deviations of the gantry, collimator and couch isocenter measurements to the phantom position were determined. Additionally, a dose measurement in the phantom was performed and compared to the dose predicted in the treatment planning system. To validate the results obtained with the in-house designed phantom, comparative measurements with commercial phantoms were performed. According to the performed end-to-end test, 2 out of the 3 linacs showed isocenter variations larger than 1 mm for collimator and gantry rotations and larger than 2 mm for couch rotations. With an isocenter variation of less than 1 mm for collimator and gantry rotations, 1 linac fulfilled the tolerance for stereotactic treatments without couch rotation. With couch rotation, an isocenter variation of less than 2 mm was detected at this linac, which fulfilled the tolerance for IMRT treatments. The mean dose deviation between measurement and treatment planning system was 1.82% ± 1.03%. The results acquired with the UMM phantom did not show statistically significant deviations to those acquired with relevant other commercial phantoms. The novel end-to-end test procedure allows for a combined dosimetric and geometric treatment evaluation. Besides the commonly performed dose end-to-end test the geometric isocenter deviation within a patient treatment workflow was evaluated and categorized for IMRT or SBRT.

摘要

剂量学和几何学精度是确保放射治疗中患者安全治疗的重要组成部分。因此,在质量控制期间必须检查这些组件。本工作提出了一种在整个治疗链中确定几何等中心偏差的可能解决方案。此外,还描述了在与几何偏差相同的程序中测量的已建立的端到端测试工作流程的剂量测量。一个内部设计的端到端测试体模经历了标准患者治疗的整个过程,并确定了剂量学和几何学的准确性。在 3 台直线加速器(linac)上,使用锥形束计算机断层扫描或表面引导定位体模。在此位置,进行 Winston-Lutz 测试,并确定旋转机架、准直器和治疗床等中心测量值与体模位置的偏差。此外,还在体模中进行了剂量测量,并与治疗计划系统中预测的剂量进行了比较。为了验证使用内部设计的体模获得的结果,与商业体模进行了比较测量。根据进行的端到端测试,3 台直线加速器中有 2 台的准直器和旋转机架的等中心变化大于 1 毫米,而治疗床的旋转大于 2 毫米。对于准直器和旋转机架的等中心变化小于 1 毫米,1 台直线加速器在没有治疗床旋转的情况下满足立体定向治疗的公差。在治疗床旋转的情况下,在该直线加速器上检测到的等中心变化小于 2 毫米,满足调强放射治疗的公差。测量值与治疗计划系统之间的平均剂量偏差为 1.82%±1.03%。使用 UMM 体模获得的结果与使用相关其他商业体模获得的结果没有统计学上的显著差异。新的端到端测试程序允许对剂量学和几何学治疗进行综合评估。除了通常进行的剂量端到端测试外,还评估了患者治疗工作流程中的几何等中心偏差,并对调强放射治疗或立体定向放射治疗进行了分类。

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