Robinson G B
Brain Res. 1986 Jul 30;379(1):56-62. doi: 10.1016/0006-8993(86)90254-4.
High-frequency activation of the entorhinal cortical (perforant path) inputs to the rat dentate gyrus can produce a long-term potentiation (LTP) of perforant path-dentate evoked responses. In this paper we examined the enhanced LTP effects produced by coactivation of septal and entorhinal inputs to the dentate gyrus. Trains of electrical stimulation applied to the two inputs were found to increase the magnitude of LTP to a level above that produced by trains applied to the perforant path alone. The largest LTP increments were observed when the septal trains were applied less than 100 ms prior to the perforant path trains. If the septal trains followed the perforant path trains there was no additional increment in LTP magnitude, regardless of the intertrain interval. The relationship of this cooperativity effect to mechanisms of associative learning is discussed.
对大鼠齿状回的内嗅皮质（穿通通路）输入进行高频激活可产生穿通通路 - 齿状回诱发反应的长时程增强（LTP）。在本文中，我们研究了对齿状回的隔区和内嗅输入进行共同激活所产生的增强的LTP效应。发现施加于这两种输入的电刺激串可将LTP的幅度增加到高于单独施加于穿通通路的刺激串所产生的水平。当隔区刺激串在穿通通路刺激串之前不到100毫秒施加时，观察到最大的LTP增量。如果隔区刺激串跟随穿通通路刺激串，则无论刺激串间隔如何，LTP幅度都不会有额外增加。讨论了这种协同效应与联想学习机制的关系。
