Association Between Dystonia-Related Genetic Loci and Parkinson's Disease in Eastern China.

BACKGROUND

Parkinson's disease (PD) and dystonia are closely related in terms of pathophysiology and clinical manifestations, but their common genetic characteristics remain unclear. Some genome-wide association studies (GWASs) and replication studies have revealed correlations between single nucleotide polymorphisms (SNPs) of the genes and dystonia. This study was conducted to assess the association between these genetic loci and PD in a population from Eastern China.

METHODS

We genotyped the SNPs (rs11655081 of ; rs6265 of ; rs61973742, rs1338051, rs9518384, and rs9518385 of ; rs67863238 of ; rs10930717 of ; and rs35875350 of ) in a cohort of 474 patients with PD and 439 healthy controls from East China. To determine the genotypes of these SNPs, we used an Agena MassARRAY Typer 4.0. Odds ratios (s) and 95% s were computed to evaluate the correlations between these SNPs and the risk of PD.

RESULTS

There were significant differences in the genotype distribution ( = 0.649, 95% = 0.478-0.880) and minor allele frequency (MAF) ( = 0.703, 95% = 0.533-0.929) of SNP rs61973742 () between patients with PD and healthy controls. A significant difference was detected in the genotype distribution of rs11655081 () ( = 1.486, 95% = 1.080-2.045).

CONCLUSION

Single nucleotide polymorphisms rs11655081 () and rs61973742 () may be associated with PD. The C allele of rs11655081 may increase the risk of PD, whereas the G allele of rs61973742 may be a protective factor.