Li Ming, Xu Yi, Wu Jiaqi, Wu Chuanjie, Li Ang, Ji Xunming
China-America Institute of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Department of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China.
Front Genet. 2022 Feb 22;13:795479. doi: 10.3389/fgene.2022.795479. eCollection 2022.
Mendelian randomization was used to evaluate the potential causal association between N-terminal probrain natriuretic peptide (NT-proBNP) and ischemic stroke based on summary statistics data from large-scale genome-wide association studies. Three single-nucleotide polymorphisms (SNPs) rs198389, rs13107325, and rs11105306 associated with NT-proBNP levels found in large general populations and in patients with acute heart disease were used as instrumental variables. The results of genetic association analysis of each single SNP show that there is no significant association between NT-proBNP levels and ischemic stroke or its subtypes, whereas rs198389 alone has a suggestive association with large-artery atherosclerosis stroke. The MR analysis of three SNPs shows that NT-proBNP levels may reduce the risk of small-vessel occlusion stroke suggestively. This genetic analysis provides insights into the pathophysiology and treatment of ischemic stroke.
基于大规模全基因组关联研究的汇总统计数据，采用孟德尔随机化方法评估N端脑钠肽前体（NT-proBNP）与缺血性卒中之间的潜在因果关联。在一般人群和急性心脏病患者中发现的与NT-proBNP水平相关的三个单核苷酸多态性（SNP），即rs198389、rs13107325和rs11105306，被用作工具变量。每个单SNP的遗传关联分析结果显示，NT-proBNP水平与缺血性卒中及其亚型之间无显著关联，而仅rs198389与大动脉粥样硬化性卒中存在提示性关联。三个SNP的孟德尔随机化分析显示，NT-proBNP水平可能提示性降低小血管闭塞性卒中的风险。该遗传分析为缺血性卒中的病理生理学和治疗提供了见解。
