Photostable fluorescent probes based on multifunctional group substituted naphthalimide dyes for imaging of lipid droplets in live cells.
作者信息
Li Xinwei, Bian Jiqing, Fu Mingyang, Zhang Yan, Liu Hongmei, Gao Baoxiang
机构信息
College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, China.
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, Baoding 071002, Hebei, China.
出版信息
Anal Methods. 2022 Mar 24;14(12):1279-1284. doi: 10.1039/d2ay00104g.
We designed and synthesized multifunctional group substituted naphthalimide (MFGNI) dyes by introducing glycine ethyl ester and azetidine on 1,8-naphthalimide. With different azetidine substituents, the emission of the MFGNI dyes was shifted from blue to green. These MFGNI dyes exhibited high photoluminescence quantum yields (61% to 85%) and large Stokes shifts (67 nm). The amides and hydroxyl groups improved the photostability of the MFGNI dyes. Due to the small molecular weight and lipophilic properties, these MFGNI dyes specifically stained lipid droplets in living cells.
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