早期帕金森病的胃肠道症状与多巴胺转运体不对称性。
Gastrointestinal Symptoms and Dopamine Transporter Asymmetry in Early Parkinson's Disease.
机构信息
Department of Neurology, Helsinki University Hospital, and Clinicum, University of Helsinki, Helsinki, Finland.
Clinical Neurosciences, University of Turku, and Neurocenter, Turku University Hospital, Turku, Finland.
出版信息
Mov Disord. 2022 Jun;37(6):1284-1289. doi: 10.1002/mds.28986. Epub 2022 Mar 11.
BACKGROUND
The neurophysiological correlates of gastrointestinal symptoms (GISs) in Parkinson's disease (PD) are not well understood. It has been proposed that in patients with a gastrointestinal origin of PD dopaminergic neurodegeneration would be more symmetric.
OBJECTIVES
The aim is to assess the associations between GISs and asymmetry of nigrostriatal dopaminergic neurodegeneration in PD.
METHODS
Ninety PD patients were assessed using motor and GIS scales and I-FP-CIT SPECT. We calculated the asymmetry index and the predominant side of motor symptoms and dopamine transporter (DAT) imaging defect and assessed their association with GISs.
RESULTS
There were no significant differences in GISs between symmetric and asymmetric dopaminergic defect. Left predominant defect was related to more GIS and higher constipation scores.
CONCLUSIONS
GISs were associated with left predominant reduction in putaminal DAT binding but not asymmetry per se. It remains open whether left-sided DAT deficit is related to more pronounced GI involvement or symptom perception in PD. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson Movement Disorder Society.
背景
帕金森病（PD）患者胃肠道症状（GISs）的神经生理学相关性尚不清楚。有人提出，PD 胃肠道起源患者的多巴胺能神经退行性变更对称。
目的
旨在评估 GISs 与 PD 中黑质纹状体多巴胺能神经退行性变的不对称性之间的关系。
方法
90 例 PD 患者接受运动和 GIS 量表以及 I-FP-CIT SPECT 评估。我们计算了运动症状和多巴胺转运体（DAT）成像缺陷的不对称指数和优势侧，并评估了它们与 GISs 的关系。
结果
多巴胺能缺陷对称和不对称之间的 GISs 无显著差异。左侧优势缺陷与更多的 GIS 和更高的便秘评分相关。
结论
GISs 与壳核 DAT 结合的左侧优势减少有关，但与不对称本身无关。左侧 DAT 缺陷是否与更明显的胃肠道受累或 PD 中的症状感知有关仍有待确定。© 2022 作者。运动障碍由 Wiley Periodicals LLC 代表国际帕金森运动障碍协会出版。
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