College of Life and Environmental Science, University of Exeter, Exeter, UK.
Independent, Oxford, UK.
Int J Rheum Dis. 2022 Jun;25(6):635-649. doi: 10.1111/1756-185X.14315. Epub 2022 Mar 10.
To examine the effect of exercise training programs with aerobic components on C-reactive protein, erythrocyte sedimentation rate and self-assessed disease activity in people with ankylosing spondylitis compared to non-aerobic rehabilitation.
A systematic review was undertaken of PubMED, Cochrane Library, Embase and Web of Science databases. Articles evaluating the effect of exercise training programs with aerobic components on C-reactive protein, erythrocyte sedimentation rate or Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in adults (>17 years) with ankylosing spondylitis were included. Control groups were defined as non-aerobic rehabilitation, including usual care or physiotherapy.
Thirteen articles met inclusion criteria for qualitative and meta-analysis, involving 366 participants undertaking exercise and 361 controls. Exercise programs included modalities such as running, aerobic walking and swimming, and were between 3 weeks and 3 months in duration. Exercise programs significantly reduced C-reactive protein (weighted mean difference [WMD]: -1.09; 95% CI: -2.08 to -0.10; P = .03; n = 5) and BASDAI (WMD: -0.78; 95% CI: -0.98 to -0.58; P < .001; n = 13) compared to non-aerobic rehabilitation. BASDAI subgroup analysis revealed greater improvements compared to usual care than structured physiotherapy. Exercise programs did not reduce erythrocyte sedimentation rate (WMD: 0.16; 95% CI: -2.15 to 2.47; P = .89; n = 4).
Exercise training programs with aerobic components reduced C-reactive protein and improved self-assessed disease activity in people with ankylosing spondylitis. Further research is required to investigate the effects of differing aerobic exercise modes, intensities and durations.
与非有氧运动康复相比，研究包含有氧运动成分的运动训练方案对强直性脊柱炎患者 C 反应蛋白、红细胞沉降率和自我评估疾病活动的影响。
对 Pubmed、Cochrane 图书馆、Embase 和 Web of Science 数据库进行系统评价。纳入评估包含有氧运动成分的运动训练方案对 C 反应蛋白、红细胞沉降率或 Bath 强直性脊柱炎疾病活动指数（BASDAI）的影响的文章，纳入对象为年龄大于 17 岁的成人强直性脊柱炎患者。对照组定义为非有氧运动康复，包括常规护理或物理治疗。
13 篇文章符合纳入标准，进行了定性和荟萃分析，涉及 366 名接受运动的参与者和 361 名对照组。运动方案包括跑步、有氧步行和游泳等方式，持续时间为 3 周至 3 个月。与非有氧运动康复相比，运动方案显著降低了 C 反应蛋白（加权均数差[WMD]：-1.09；95%可信区间：-2.08 至 -0.10；P = 0.03；n = 5）和 BASDAI（WMD：-0.78；95%可信区间：-0.98 至 -0.58；P < 0.001；n = 13）。BASDAI 亚组分析显示，与常规护理相比，与结构化物理治疗相比，改善更为显著。运动方案并未降低红细胞沉降率（WMD：0.16；95%可信区间：-2.15 至 2.47；P = 0.89；n = 4）。
包含有氧运动成分的运动训练方案降低了 C 反应蛋白，并改善了强直性脊柱炎患者的自我评估疾病活动。需要进一步研究不同的有氧运动模式、强度和持续时间的影响。
