Schiff R D, Oliff A
Crit Rev Oncol Hematol. 1986;5(3):257-323. doi: 10.1016/s1040-8428(86)80041-5.
Murine leukemia viruses (MuLVs) are retroviruses which induce a broad spectrum of hematopoietic malignancies. In contrast to the acutely transforming retroviruses, MuLVs do not contain transduced cellular genes, or oncogenes. Nonetheless, MuLVs can cause leukemias quickly (4 to 6 weeks) and efficiently (up to 100% incidence) in susceptible strains of mice. The molecular basis of MuLV-induced leukemia is not clear. However, the contribution of individual viral genes to leukemogenesis can be assayed by creating novel viruses in vitro using recombinant DNA techniques. These genetically engineered viruses are tested in vivo for their ability to cause leukemia. Leukemogenic MuLVs possess genetic sequences which are not found in nonleukemogenic viruses. These sequences control the histologic type, incidence, and latency of disease induced by individual MuL Vs.
鼠白血病病毒（MuLVs）是逆转录病毒，可诱发多种造血系统恶性肿瘤。与急性转化型逆转录病毒不同，MuLVs不包含转导的细胞基因或癌基因。尽管如此，MuLVs可在易感小鼠品系中迅速（4至6周）且高效地（发病率高达100%）引发白血病。MuLV诱发白血病的分子基础尚不清楚。然而，可通过使用重组DNA技术在体外构建新型病毒来检测单个病毒基因对白血病发生的作用。这些基因工程病毒在体内进行致白血病能力测试。致白血病的MuLVs拥有非致白血病病毒中未发现的基因序列。这些序列控制着由单个MuLVs诱发疾病的组织学类型、发病率和潜伏期。
